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Cefuroxime axetil pharmaceutical composition

A technology of cefuroxime axetil and cefuroxime, which is applied in the field of cefuroxime axetil pharmaceutical composition, can solve the problems affecting the dissolution of drugs, and achieve the effects of high dissolution rate, high bioavailability and good stability

Active Publication Date: 2013-10-16
ZHEJIANG RUIXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Due to the bitter taste of cefuroxime axetil, it is easy to gel with the water-soluble medium, thus affecting the dissolution of the drug

Method used

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  • Cefuroxime axetil pharmaceutical composition
  • Cefuroxime axetil pharmaceutical composition
  • Cefuroxime axetil pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Cefuroxime Axetil Capsules

[0034] 1000 capsules are formulated with the following components by weight ratio:

[0035]

[0036]

[0037] Here, the weight of the cefuroxime axetil is calculated by cefuroxime.

[0038] Preparation:

[0039] (1) Separately pulverize micropowder silica gel, sodium carboxymethyl starch and sodium lauryl sulfate, sieve and dry;

[0040] (2) Weigh cefuroxime axetil, mix it with the micropowder silica gel obtained in step (1), sodium lauryl sulfate and 2 / 3 parts by weight of sodium carboxymethyl starch, and directly granulate it by dry method. Granules, add the remaining amount of sodium carboxymethyl starch, mix evenly, detect intermediates, pack into capsules, pack, and get ready.

Embodiment 2

[0042] Cefuroxime Axetil Capsules

[0043] 1000 capsules are formulated with the following components by weight ratio:

[0044]

[0045] Here, the weight of the cefuroxime axetil is calculated by cefuroxime.

[0046] Preparation:

[0047] (1) Separately pulverize micropowder silica gel, sodium carboxymethyl starch and sodium lauryl sulfate, sieve and dry;

[0048] (2) Weigh cefuroxime axetil, mix it with the micropowder silica gel obtained in step (1), sodium lauryl sulfate and 2 / 3 parts by weight of sodium carboxymethyl starch, and directly granulate it by dry method. Granules, add the remaining amount of sodium carboxymethyl starch, mix evenly, detect intermediates, pack into capsules, pack, and get ready.

Embodiment 3

[0050] Cefuroxime Axetil Capsules

[0051] 1000 capsules are formulated with the following components by weight ratio:

[0052]

[0053] Here, the weight of the cefuroxime axetil is calculated by cefuroxime.

[0054] Preparation:

[0055] (1) Separately pulverize micropowder silica gel, sodium carboxymethyl starch and sodium lauryl sulfate, sieve and dry;

[0056] (2) Weigh cefuroxime axetil, mix it with the micropowder silica gel obtained in step (1), sodium lauryl sulfate and 2 / 3 parts by weight of sodium carboxymethyl starch, and directly granulate it by dry method. Granules, add the remaining amount of sodium carboxymethyl starch, mix evenly, detect intermediates, pack into capsules, pack, and get ready.

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PUM

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Abstract

The invention discloses a cefuroxime axetil pharmaceutical composition which is a capsule. Every 1000 capsules are prepared by the following components in percentage by weight: 80 g to 180 g of cefuroxime axetil, 10 g to 80 g of superfine silica powder, 20 g to 120 g of carboxymethyl starch sodium and 0.5 g to 9 g of lauryl sodium sulfate; in addition, the invention further discloses a preparation method of the cefuroxime axetil pharmaceutical composition. The cefuroxime axetil pharmaceutical composition has the characteristics of good stability, high dissolution rate, simple formula and high relative bioavailability, and is better suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and more specifically relates to a cefuroxime axetil pharmaceutical composition. Background technique [0002] Cefuroxime Axetil, English name: Cefuroxime Axetil, molecular formula: C 20 h 22 N 4 o 10 S, is a second-generation cephalosporin antibiotic; after oral administration and absorption through the gastrointestinal tract, it is rapidly hydrolyzed into cefuroxime under the action of esterase to exert antibacterial effect. [0003] Glaxo disclosed the cefuroxime compound in the US patent (patent No. US3974153) granted in 1976. In addition, the company disclosed the preparation method of cefuroxime axetil in the authorized US patent (patent No. US4267320) in 1981. [0004] Nanjing Normal University discloses a pharmaceutical composition containing cefuroxime axetil cyclodextrin inclusion complex in Chinese patent application CN200710004557.2, the basic composition of which includes: a) c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K31/546A61P31/04
Inventor 吴丽仙徐亮满宗敏胡富苗
Owner ZHEJIANG RUIXIN PHARMA
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