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Application of SIRT2 inhibitor in pharmacy

A 1. SIRT2, inhibitor technology, applied in the field of medicine, can solve the problems of no literature reports, no related reports on the impact and treatment, and achieve significant effects

Inactive Publication Date: 2013-11-20
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0008] There is no literature report on the relationship between SIRT2 and insulin secretion, and there is no relevant report on the effect and treatment of SIRT2 inhibitor AGK2 on insulin secretion

Method used

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  • Application of SIRT2 inhibitor in pharmacy
  • Application of SIRT2 inhibitor in pharmacy
  • Application of SIRT2 inhibitor in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Below in conjunction with embodiment, the present invention will be further described:

[0022] The rat model used in the experiment was SPF (Specific pathogen Free) grade SD (Sprague-Dawley) rat, male, 8-10 weeks old, weighing 200-250g, purchased from the Slack Experimental Animal Center of the Chinese Academy of Sciences in Shanghai; SPF grade C57BL / 6 mice, male, 8-10 weeks old, were purchased from the Slack Experimental Animal Center of Shanghai Chinese Academy of Sciences.

[0023] 1. Expression and localization of SIRT2 in mouse pancreas tissue, rat primary islet β cells and MIN6 cells

[0024] The results of immunofluorescence test showed that SIRT2 was mainly expressed in islet cells in pancreatic tissue; in primary rat islet β cells and MIN6 cells, SIRT2 was mainly located in the cytoplasm. SIRT2 is abundant in islets and MIN6 cells, indicating that SIRT2 plays an important role in regulating the function of islet β cells.

[0025] 2. Effect of AGK2 on acetyl...

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Abstract

The invention relates to the technical field of medicines, in particular to application of an SIRT2 (Sirtuin 2) inhibitor in preparation of drugs treating type 2 diabetes and drugs inhibiting insulin secretion. The acute effect test of AGK2 on rat islet glucose stimulated insulin secretion (GSIS), the test of the influence of different concentrations of AGK2 on insulin secretion, the test of the influence of AGK2 on insulin secretion under different glucose concentrations, and the test experiment of the acute effect of AGK2 on high concentration glucose induced insulin hypersecretion together prove that the SIRT2 inhibitor AGK2 can obviously inhibit glucose stimulated insulin secretion, and the AGK2 with a concentration of 0.5 micromol / l already can inhibit insulin secretion, thus providing exact experimental data for preparation of drugs treating type 2 diabetes, and also providing more scientific bases for clinically more rational use of AGK2.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a SIRT2 inhibitor in the preparation of a drug for treating type 2 diabetes and in the preparation of a drug for inhibiting insulin secretion. Background technique [0002] Diabetes is one of the major chronic diseases that seriously endanger human health. At present, the number of diabetic patients in the world is about 240 million, and the prevalence rate is still increasing. Type 2 diabetes patients account for 90%-95%. If the blood sugar control is not satisfactory, patients with type 2 diabetes are more likely to be harassed by various complications of diabetes. Patients will suffer from blindness, uremia, physical disability and cardiovascular and cerebrovascular diseases. So type 2 diabetes and its complications seriously endanger human health and bring huge economic burden to the society. [0003] Islet dysfunction of type 2 diabetes is an important l...

Claims

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Application Information

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IPC IPC(8): A61K31/4709A61P3/10A61P5/48
Inventor 宁光建方方王晓周丽斌
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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