Carragheenan and potassium chloride gelled hydroxypropyl methylcellulose enteric-coated hollow capsule

A technology of hypromellose and hollow capsules, which is applied in capsule delivery, cosmetic preparations, medical preparations of non-active ingredients, etc., and can solve the problem of insufficient film formation and storage stability of capsules and the disintegration speed of gelatin capsules Slow, hollow capsule safety hazards and other problems, to reduce the risk of drug hygroscopicity, no risk of animal infectious diseases, not easy to rot and deteriorate

Active Publication Date: 2013-11-20
SICHUAN TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, gelatin capsules obviously have the defect of slow disintegration speed. At the same time, the huge gelatin empty capsule market and its industrial chain have also brought many quality problems and safety risks.
After the "Chromium Exceeding Standard Capsule Incident", more attention has been paid to the safety issues of capsules; at the same time, with the occurrence of animal diseases such as "mad cow disease" and "foot-and-mouth disease", people have a lot of interest in making gelatin raw materials from animal leather and bones. There is great anxiety, the empty capsules mainly produced from animal gelatin have great potential safety hazards
[0005

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 10kg of hypromellose, put it into 33L of purified water with a temperature of 77°C, stir continuously at a stirring speed of 1550rpm and cool it naturally to 22°C, then keep it for 60 minutes, and then heat the solution to 35°C to obtain hydroxypropyl methylcellulose Methocel solution; then take 40g of carrageenan and dissolve it in 3.8L of purified water at a temperature of 35°C, stir for 5min at a speed of 2550rpm, add it to the hypromellose solution after it is completely dissolved, and continue stirring for 3min at a speed of 1550rpm , and mix evenly; then take 54g of potassium chloride and add it to the hypromellose solution, continue to stir at a speed of 1550rpm and naturally cool to 22°C, let it stand for 2 minutes, then heat the solution to 35°C, and then keep it for 60 minutes , to get impregnated stable colloidal solution, then dipped in glue to form a mold, and then dried at 30°C to obtain a dry capsule stick; then dipped the capsule stick into the organ...

Embodiment 2

[0025] Take 50kg of hypromellose, put it into 170L of purified water with a temperature of 80°C, stir continuously at a stirring speed of 1600rpm and cool it naturally to 25°C, then keep it for 75 minutes, and then heat the solution to 40°C to obtain hydroxypropyl methylcellulose Methocel solution; then take 205g of carrageenan and dissolve it in 20L of purified water at a temperature of 45°C, stir at a speed of 2600rpm for 4min, add it to the hypromellose solution after it is completely dissolved, and continue stirring at a speed of 1600rpm for 2.5min , mix evenly; then take 276g of potassium chloride and add it to the hypromellose solution, continue to stir at a speed of 1600rpm and cool it down to 25°C naturally, let it stand for 2.5min, then heat the solution to 45°C, and then keep it warm After 90 minutes, a stable colloidal solution was obtained, then dipped in glue to form a mold, and then dried at 32°C to obtain a dry capsule stick; then the capsule stick was immersed i...

Embodiment 3

[0027] Take 100kg of hypromellose, put it into 350L of purified water with a temperature of 83°C, stir continuously at a stirring speed of 1650rpm and cool it naturally to 28°C, then keep it for 90 minutes, and then heat the solution to 45°C to obtain hydroxypropyl methylcellulose Methocel solution; then take 420g of carrageenan and dissolve it in 42L of purified water at a temperature of 40°C, stir at a speed of 2650rpm for 3min, add it to the hypromellose solution after it is completely dissolved, and continue to stir at a speed of 1650rpm for 2min, Mix evenly; then take 560g of potassium chloride and add it to the hypromellose solution, continue to stir at a speed of 1650rpm and naturally cool to 28°C, let it stand for 3 minutes, then heat the solution to 40°C, and then keep it for 120 minutes. Get impregnated and stable colloidal solution, then dip into the glue to form a mold, and then dry at 35°C to obtain a dry capsule stick; then immerse the capsule stick in the hyprome...

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PUM

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Abstract

The invention relates to a carragheenan and potassium chloride gelled hydroxypropyl methylcellulose enteric-coated hollow capsule, and belongs to the technical field of the production of hollow capsules. The hollow capsule is characterized in that the hollow capsule is prepared through mixing a main raw material hydroxypropyl methylcellulose with carragheenan and potassium chloride under a special condition, the hollow capsule has the characteristics of timely disintegration, low water content, suitableness for medicines having strong hygroscopic property and being sensitive to water, small influences of a dissolve-out medium to the shell of the capsule, high drug compliance, long storage duration data, no deterioration within 3-4 years, low condition requirements on the storage and the transportation, difficult crushing in the low humidity environment, difficult deformation, putrefaction and deterioration in the high temperature environment, according with the requirements of populations having all culture backgrounds because of pure vegetable fibers, almost no pollution in the production process, secondary re-dissolving utilization of tailings, omission of the commonly-used surfactants and plasticizers, acceleration of the gelling speed by reducing the gelling temperature only through utilizing potassium chloride to assist the carragheenan, additive reduction, production cost reduction, and suitableness for the mass popularization.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule made of carrageenan and potassium chloride gel prepared from hypromellose. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] The current hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In my country, gelatin hollow capsules account for the vast majority. At present, gelatin hollow capsules have been widely...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K9/48A61K8/11
Inventor 陈光伦张强
Owner SICHUAN TIANSHENG PHARMA
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