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High-sensitivity fullerene photoelectric chemical probe and preparation method thereof

A photoelectrochemical and fullerene technology, applied in the direction of material electrochemical variables, etc., can solve the problems such as the work report of fullerene photoelectrochemical probes, which is convenient for long-term storage and use, high water solubility, and good water solubility. Effect

Active Publication Date: 2015-01-21
WUHAN UNIV
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  • Claims
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Problems solved by technology

However, there have been no work reports and related products of fullerene photoelectrochemical probes at home and abroad so far.

Method used

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  • High-sensitivity fullerene photoelectric chemical probe and preparation method thereof
  • High-sensitivity fullerene photoelectric chemical probe and preparation method thereof
  • High-sensitivity fullerene photoelectric chemical probe and preparation method thereof

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Embodiment Construction

[0023] The fullerene photoelectrochemical probe of the present invention includes a carboxylated nano-carrier, the azo dye is fixed on the surface of the carboxylated nano-carrier through π-π interaction, and the fullerene is indirectly fixed on the carboxyl group through the π-π interaction with the azo dye. On the surface of the carboxylated nanocarrier, the detection antibody is immobilized by forming a covalent bond with the carboxyl group on the surface of the carboxylated nanocarrier.

[0024] The invention realizes the high-efficiency aqueous dispersion of fullerene-type photoelectric probes through the surface modification of fullerene-nano-carrier photoelectric composite materials by azo dyes, and realizes the fullerene photoelectric probes by using derivatizable carboxyl groups on nano-carriers Antibody labeling, using the principle of sandwich immunology to achieve highly sensitive photoelectrochemical detection of the antigen to be tested.

[0025] The preparat...

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Abstract

The invention relates to a preparation method of a high-sensitivity fullerene photoelectric chemical probe. The method is based on non-covalent modification of bisazo dye molecules on a fullerene photoelectric composite material and covalent fixation of biomolecules on the surface of the material, so that a water-soluble photoelectric chemical probe is prepared. A common electrochemical analyser and a low-cost laser pointer monochromatic source are adopted, the fullerene photoelectric chemical probe is taken as a marking probe of a detection antibody in a sandwich immune structure, high-sensitivity detection that tumor marker CEA (carcino embryonie antigen) is reduced to 0.1 pg / mL can be realized, the sensitivity of the probe can be compared with that of a common electrochemiluminescence method in the current clinic, a detection device can be integrated easily and is portable and low in cost, and the probe has an application prospect in clinical high-sensitivity biochemical analysis.

Description

technical field [0001] The invention relates to a highly sensitive fullerene photoelectrochemical probe and a preparation method thereof, belonging to the field of biological detection. Background technique [0002] The photoelectrochemical (PEC) sensing technology based on the photoinduced electron transfer process uses light signals to drive heterogeneous electron transfer at the sensor interface, and uses electrochemical analyzers to measure the photocurrent / voltage signals generated by photoelectric conversion. Except for the addition of light source, the photoelectrochemical sensing technology is basically the same as electrochemical analysis in terms of detection equipment, measurement methods and signal processing, so it has the characteristics of high sensitivity, high integration and low cost of electrochemical methods. Contrary to the electrochemiluminescence technology commonly used in clinical biochemical analysis, the photoelectrochemical method uses light excit...

Claims

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Application Information

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IPC IPC(8): G01N27/26
Inventor 胡成国胡胜水郑金偶
Owner WUHAN UNIV
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