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Microneedle devices and methods

A technology of microneedles and microneedle arrays, which is applied in the direction of microneedles, needles, and pharmaceutical formulations, and can solve the problems of expensive system manufacturing

Active Publication Date: 2013-11-20
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such systems are significantly more expensive to manufacture

Method used

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  • Microneedle devices and methods
  • Microneedle devices and methods
  • Microneedle devices and methods

Examples

Experimental program
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Effect test

example 1

[0174] Preparations containing lidocaine and clonidine

[0175] The microneedle array uses a surface area of ​​about 1.27 cm 2 Class VI medical grade liquid crystal polymer (LCP) ( MT1300 was obtained from Ticona Plastics, Auburn Hills, Michigan, USA and was injection molded (3M Company, St. Paul, MN, USA). Each microneedle array is characterized by 316 quadrangular pyramidal microneedles arranged in an octagonal pattern, where the height of the microneedles is nominally 500 μm, the aspect ratio is about 3:1, and the tips between adjacent microneedles reach The tip distance is nominally 550 microns.

[0176] Using the dip-coating method, a mixture of 30% dextran (Pharmacosmos, Holbaek, Denmark), 30% lidocaine hydrochloride (Sigma-Aldrich, St. Sigma, St.Louis, MO)) and 0.3% clonidine hydrochloride (Spectrum Chemical & Laboratory Products (Spectrum Chemical & Laboratory Products, New Brunswick, NJ) of New Brunswick, New Jersey, U.S.A.) on the microneedle array. Prior to ...

example 2

[0187] Preparations containing lidocaine and epinephrine

[0188] The microneedle array uses a surface area of ​​about 1.27 cm 2 Class VI medical grade liquid crystal polymer (LCP) ( MT1300 was obtained from Ticona Plastics, Auburn Hills, Michigan, USA and was injection molded (3M Company, St. Paul, MN, USA). Each microneedle array is characterized by 316 quadrangular pyramidal microneedles arranged in an octagonal pattern, where the height of the microneedles is nominally 500 μm, the aspect ratio is about 3:1, and the tips between adjacent microneedles reach The tip distance is nominally 550 microns.

[0189] A mixture of 30% dextran (Pharmacosmos, Holbaek, Denmark), 30% lidocaine hydrochloride (Sigma-Aldrich, St. Louis, MO, USA) was used by dip coating. Sigma, St.Louis, MO)) and 0.03% epinephrine tartrate (Sigma, St.Louis, MO, USA, Sigma, St.Louis, MO) to apply lidocaine to the microneedle array superior. Prior to coating, microneedle arrays were cleaned with 70% iso...

example 3

[0200] Preparations containing prilocaine and clonidine

[0201] The microneedle array uses a surface area of ​​about 1.27 cm 2 Class VI medical grade liquid crystal polymer (LCP) ( MT1300 was obtained from Ticona Plastics, Auburn Hills, Michigan, USA and was injection molded (3M Company, St. Paul, MN, USA). Each microneedle array is characterized by 316 quadrangular pyramidal microneedles arranged in an octagonal pattern, where the height of the microneedles is nominally 500 μm, the aspect ratio is about 3:1, and the tips between adjacent microneedles reach The tip distance is nominally 550 microns.

[0202] A mixture of 30% dextran (from Pharmacosmos, Holbaek, Denmark), 15% prilocaine hydrochloride (Spectrum Chemical & Laboratory, New Brunswick, NJ, USA) was used by dip coating. Products (Spectrum Chemical & Laboratory Products, New Brunswick, NJ)) and 0.15% clonidine hydrochloride (Spectrum Chemical & Laboratory Products (Spectrum Chemical & Laboratory Products, New B...

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Abstract

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component / local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component / local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

Description

[0001] This application claims the benefit of US Provisional Application No. 61 / 449,993, filed March 7, 2011, which is hereby incorporated by reference in its entirety. Background technique [0002] Transdermal delivery of therapeutic agents (eg, drugs) through the skin to local tissues or the systemic circulatory system without piercing the skin, such as using transdermal patches, has been used successfully in some pharmaceuticals. This type of passive delivery involves diffusion of the agent across at least the stratum corneum, where the rate of diffusion through the stratum corneum can be rate limiting. [0003] Active delivery of therapeutic agents is practiced in certain instances to increase flux of the agent through the stratum corneum. In this case an external energy source (eg, electrical potential, ultrasound, or heat) is applied to aid transport of the agent through the stratum corneum or through the skin. [0004] The amount of drug delivered transdermally is also...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61M37/00
CPCA61M2037/0046A61M37/0015A61M2037/0061A61K9/0021A61M2037/0023A61P23/02A61P25/02A61P43/00A61K9/00A61M37/00
Inventor 张莹克里斯滕·J·汉森埃米·S·德特曼
Owner 3M INNOVATIVE PROPERTIES CO
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