subretinal stem cell transplant

Abstract

Disclosed is a subretinal space stem cell transplanter, comprising a needle (1), a sleeve (3), an injection power boosting tube (7) and a rotary cover (10) which are sequentially mounted and connected with each other and further comprising a linear motor, a power source, a control switch (12), a quantitative storage tube (2) arranged on the sleeve (3) and used for pre-filling stem cells and a limiting fixing part (6), wherein a guide hole is formed in the limiting fixing part (6), a primary (8) of the linear motor is mounted and fixed in the injection power boosting tube (7), one end of a secondary (9) of the linear motor penetrates through the guide hole of the limiting fixing part (6) and then is fixedly connected with a pushing and pressing part (5), one end of the quantitative storage tube (2) is correspondingly communicated with the needle (1), a piston (4) is arranged at the other end of the quantitative storage tube (2), and the piston (4) corresponds to the pushing and pressing part (5); and the control switch (12) is mounted in the front-end area, close to the needle (1), of the sleeve (3). The transplanter is simple in operation, safe and reliable, avoids the risk of retinas perforation due to uncooperative operation of two persons, obviously reduces the transplanting difficulty, and improves the subretinal space stem cell transplanting effect.

Description

technical field [0001] The invention belongs to the field of medical equipment, in particular to a subretinal space stem cell transplanter used in operations in clinical and experimental ophthalmology. Background technique [0002] Currently the most common blinding eye diseases include cataract, corneal disease, glaucoma and retinal degenerative diseases (including age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and retinal degeneration caused by high myopia, etc.). Among them, cataract, which accounts for the first cause of blindness (60%), can be restored by increasingly perfect modern cataract extraction and intraocular lens implantation surgery; glaucoma is mainly controlled by early prevention and later drug or surgery, which partially meets the quality of life of patients. Retinal degenerative diseases are the most common cause of blindness in developed countries (more than 50%). In my country, nearly 200,000 patients are blinded by such d...

AI Technical Summary

Problems solved by technology

[0004] (1) It is difficult for the operator to coordinate with the assistant, and the needle can easily penetrate the retina and enter the vitreous cavity if there is a slight carelessness, causing retinal hemorrhage if the retinal blood vessel is pierced, and in severe cases, intraocular hemorrhage, resulting in failure of subretinal cavity transplantation. The success rate of subretinal space stem cell transplantation with microinjector is about 40-50%

[0005] (2) When injecting into the subretinal cavity with a micro-syringe, the amount and scope of cell injection cannot be controlled, and hills of transplanted cells are formed at the injection site, and the accumulation of cells can cause differences in the distribution of nutrition, secretion, metabolism, and polarity of cells. Balanced, severe impact on survival of subretinal space transplanted cells

[0006] (3) Since the design of the glass micro-syringe is that the needle and the syringe are integrated, the price is expensive, and the injection needle is slender. The outer diameter of the commonly used needle is 0.184-0.36mm, and the inner diameter is 0.0826-0.184mm. The disinfection of the syringe is often soaked in disinfectant. Autoclaving can reduce the sharpness of injection needles

[0007] (4) Due to the slender inner diameter of the needle, it is not easy to clean after use, and soaking in the solution may easily cause incomplete disinfection, which may cause surgical contamination

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