2-phenylaminopurine plk1 (polo-like kinase 1) inhibitors and applications thereof

An amino and purine technology, applied in the field of Polo-like kinase 1 inhibitor, 2-phenylaminopurine derivatives, can solve the problems of tumor cell bipolar spindle formation obstruction, apoptosis, growth inhibition, etc.
CN103408546AInactive Publication Date: 2013-11-27CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2013-11-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of medicinal chemistry, and in particular relates to 2-phenylaminopurine compounds, a preparation method for the compounds, a medicinal composition containing the compounds, and medical applications for the compounds, and in particular an application for the compounds as Polo-like kinase 1 inhibitors.
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Description

technical field

[0001] The present invention relates to the field of medicinal chemistry, in particular to 2-anilinopurine derivatives, their preparation methods, pharmaceutical compositions containing these compounds and their medical applications, especially as Polo-like kinase 1 (Polo-like kinase 1, Use of PLK1) inhibitors. Background technique

[0002] In recent years, tumors have surpassed cardiovascular diseases and become the world's leading cause of death. The research on anti-tumor drugs has important academic and practical significance.

[0003] Studies have found that almost all tumors are related to uncontrolled cell growth, blocked differentiation, and abnormal apoptosis caused by the disorder of cell cycle regulation mechanism. The frequency of tumor cell division is faster than that of normal cells, and various proteins that regulate microtubule polymerization, centrosome duplication, spindle formation, and cytokinesis are often overexpressed and their activi...

Claims

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