The invention provides an amion thiazolidone compound, as shown in a formula I, wherein A1 is
aryl or ceteroary; A2 is
benzene ring or substituted
benzene ring, double
benzene nucleus or substituted double benzene
nucleus,
pyridine ring (including 2-, 3-, 4-
pyridine) or substituted
pyridine ring; and R1, R2, R3, R4, R5 and R6 are respectively H,
halogen, hydroxy, cyan, amino or nitro or C1-C6
alkyl or C1-C6 alkoxy and the like; and R7 and R8 are respectively H, C1-C6
alkyl or C3-C6 naphthene base. The compound in the formula I comprises
hydrate of the compound, solvate, stereoisomer, N-
oxide, salt and crystalline forms which exist in various forms. Bioactivity tests show that: the compound in the formula I can restrain the activities of polo-like
kinase 1 (PLK1) inside and outside the
human body, and can be used for preparing antitumor drugs. The invention further provides a method for preparing the compound in the formula I.