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Drug sustained-release preparation and preparation method thereof

A technology for sustained-release preparations and prescriptions, applied in the field of harpagoside sustained-release preparations and its preparation, which can solve the problems that the antibacterial effect depends on the peak concentration and is not suitable for making controlled-release preparations

Inactive Publication Date: 2013-12-25
SUZHOU FAMO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial effect of antibacterial drugs depends on the peak concentration, so it is not suitable to be made into controlled release preparations

Method used

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  • Drug sustained-release preparation and preparation method thereof
  • Drug sustained-release preparation and preparation method thereof
  • Drug sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The present embodiment tablet contains following composition by weight percentage:

[0014]

[0015] Preparation process: Mix harpagoside with carboxymethylcellulose, lactose, and polyvinylpyrrolidone evenly, granulate with absolute ethanol, dry, granulate, add magnesium stearate, mix evenly, and compress into tablets.

Embodiment 2

[0017] The present embodiment tablet contains following composition by weight percentage:

[0018]

[0019] Preparation process: harpagoside, acrylic resin, hydroxypropyl methylcellulose, lactose, and microcrystalline cellulose are granulated with ethanol, dried, sized, and compressed with magnesium stearate.

Embodiment 3

[0021] The present embodiment tablet contains following composition by weight percentage:

[0022]

[0023]

[0024] Preparation process: Mix harpagoside with hydroxypropyl methylcellulose, lactose, microcrystalline cellulose, carboxymethylcellulose, and polyvinylpyrrolidone, granulate with absolute ethanol, dry, granulate, add hard Magnesium fatty acid is mixed and pressed into tablets.

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Abstract

The invention belongs to the pharmaceutical field, and relates to a harpagoside-containing sustained-release preparation and a preparation method thereof. The harpagoside-containing sustained-release preparation has the characteristics of convenient use and good stability, and can be widely used in the treatment of related diseases caused by coxsackie virus infection, wherein the diseases include viral myocarditis and arrhythmia induced by the viral myocarditis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a harpagoside sustained-release preparation and a preparation method thereof. Background technique [0002] Hapagoside (HPG) is an iridoid glycoside isolated from Scrophularia ningpoensis Hemsl. This ingredient is only distributed in plants such as Scrophulariaceae Scrophulariaceae, Scrophulariaceae Scrophulariae, Forest Scrophulariae, Scrophulariaceae, and Scrophulariaceae, and plants such as Scrophulariaceae and Scrophulariaceae. It is the main ingredient in traditional Chinese medicine Scrophulariaceae Scrophulariae and Harpagophytum procumbens D.C. After oral administration to rats, harpagoside was rapidly absorbed, had low bioavailability, and was rapidly eliminated after reaching the peak. [0003] Sustained-release preparations are the third-generation dosage forms developed on the basis of the concept that the curative effect of drugs is only related to the drug concentration i...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/7048A61K47/38A61K47/36A61K47/32A61P31/14A61P9/04A61P9/06
Inventor 不公告发明人
Owner SUZHOU FAMO BIOLOGICAL TECH
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