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Application of Lycojaponicumin A in medicaments for treating lung cancer

A drug and lung cancer technology, applied in the field of anti-tumor drugs, can solve the problem of damage to normal tissues and cells, and achieve the effect of strong cytotoxicity and prominent substantive characteristics

Active Publication Date: 2013-12-25
安徽创意达技术转移服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of Lycojaponicumin A in medicaments for treating lung cancer
  • Application of Lycojaponicumin A in medicaments for treating lung cancer
  • Application of Lycojaponicumin A in medicaments for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Lycojaponicumin A inhibits the proliferation of lung cancer cells cultured in vitro and its effect on normal human cells

[0018] Lung cancer cells in logarithmic growth phase (non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5) and human normal liver cell L02 were inoculated in On a 96-well culture plate, the inoculum volume per well was 3000-4000 cells / 100uL and 6000 cells / 100uL respectively; aseptically collected 15 mL of venous blood from healthy blood donors, anticoagulated with heparin, and separated mononuclear cells by Ficoll density gradient centrifugation. A single cell suspension was prepared with RPMI1640 containing 10% fetal bovine serum, adjusted to a cell concentration of 2×105 cells / mL, and inoculated in a 96-well culture plate, 100 uL per well. After 24 hours of cell culture on the above-mentioned culture plates, Lycoja...

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Abstract

The invention discloses application of Lycojaponicumin A in preparation of medicaments for treating lung cancer. The compound shows good anti-lung cancer activity, can be used for preparing anti-lung cancer medicaments, and belongs to the technical field of new application of medicaments. The Lycojaponicumin A can prominently inhibit non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous cancer cells HTB-8 and human lung flat epithelial cancer cells QG-5 cultured in vitro, has a low inhibiting effect on human normal liver cells LO2 and peripheral blood lymphocytes, and shows obvious selectivity. The application of the Lycojaponicumin A in preparation of the medicaments for treating the lung cancer is made public for the first time; and because the skeleton type is completely novel, the Lycojaponicumin A has an unexpectedly strong lung cancer cell inhibiting activity.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to the application of Lycojaponicumin A in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed through experiments that Lycojaponicumin A has significant inhibitory effect on non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5 cultured in vitro, However, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/424A61P35/00A61P11/00
Inventor 江春平王慧
Owner 安徽创意达技术转移服务有限公司
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