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Application of Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation

A technology of intestinal inflammation and cotton head snow, which is applied in the direction of medical preparations containing active ingredients, drug combinations, plant raw materials, etc.

Inactive Publication Date: 2013-12-25
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the cotton-headed snow rabbit has potential anti-inflammatory, analgesic, anti-oxidation, and free radical scavenging effects, but there is no relevant report on the Tibetan cotton-headed snow rabbit extract used to relieve intestinal inflammation

Method used

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  • Application of Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation
  • Application of Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation
  • Application of Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Tibetan Cotton Snow Rabbit Extract

[0017] Take 20g of Tibetan cotton-headed snow rabbit, cut it into pieces, add 400mL of deionized water to soak for 24 hours, heat to a slight boil for 3 hours, filter, then add 400mL of deionized water to extract twice in the same way, combine the filtrates extracted three times and heat and concentrate to 200mL, the mass concentration is 0.1g·mL -1 The cotton-headed snow rabbit extract was stored at 4°C for later use.

Embodiment 2

[0018] Example 2 The effect of the Tibetan Cotton Snow Rabbit Extract on the survival rate of fruit flies infected with B. bassiana spores

[0019] Preparation of B. bassiana spore liquid: Cultivate B. bassiana on LB solid medium for 7 days (25°C). After the spores are produced, scrape the spores and add them to PBS, oscillate fully, filter, and measure A 600 value, formulated as A 600 The spore liquid (containing 5% sucrose) with a value of 40.

[0020] Drosophila cultured in common culture medium was used as the control group, and Drosophila cultured in cotton-headed snow rabbit culture medium was used as the experimental group. Drosophila flies that had hatched for 3 to 5 days in the control group and the experimental group were randomly collected, with 15 male and female flies in each group. Drosophila in each group was starved for 2 hours and transferred to a fruit fly tube with 5 layers of filter paper, and B. bassiana spore liquid was added to fully wet the filter pap...

Embodiment 3

[0022] Embodiment 3 Tibetan Cotton Snow Rabbit Extract is to NaCl, SDS and KAl(SO 4 ) 2 Effects of treatment on the survival rate of postfly

[0023] The feeding steps are the same as above, wherein the concentration of NaCl is 0.4mol L -1 , the mass concentration of SDS is 0.6%, KAl(SO 4 ) 2 The concentration is 20mmol·L -1 .

[0024] The results showed that after adult fruit flies were treated with NaCl for 6 days, the survival rate of the control group was only 7.6%, while the survival rate of the experimental group fed with 2.5% and 5% cotton-head snow rabbits was 63.3% (P figure 2 A). After SDS treatment, the survival rates of the experimental groups fed 2.5% and 5% cotton-head snow rabbits were 45.6% (P figure 2 B). In addition, KAl(SO 4 ) 2 After treating fruit flies for 6 days, feeding 5% cotton-headed snow rabbits can significantly improve the survival rate of fruit flies (P figure 2 C). The above results show that the cotton-headed snow rabbit can alleviate ...

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Abstract

The invention discloses application of a Tibet saussurea laniceps extract to relieving fruit fly intestinal inflammation. The Tibet saussurea laniceps extract is obtained by using a water extraction method; a fruit fly intestinal immunologic function damage model repair test is performed on the Tibet saussurea laniceps extract to discover that the Tibet saussurea laniceps extract has good anti-inflammation activity and antioxidant activity and can be used for preparing anti-inflammation medicaments, particularly anti-intestinal inflammation medicaments.

Description

technical field [0001] The invention relates to the application of the extract of Tibetan cottonhead snow rabbit in alleviating intestinal inflammation of fruit flies, and relates to the technical field of natural immunity of fruit flies. Background technique [0002] The intestinal mucosa is exposed to a large amount of different antigenic substances such as food, bacteria, and viruses every day. In the intestinal tract, it produces an immune response to pathogenic microorganisms and develops immune resistance to food antigens and other normal intestinal lumen contents while eliminating pathogenic microorganisms. Intestinal mucosal barrier is required to function. Intestinal mucosal immunity against pathogenic microorganisms can be divided into innate immunity and acquired immunity, in which innate immunity forms the basis of the intestinal mucosal barrier. Intestinal innate immunity is an important defense mechanism of the intestine and the host's first line of defense ag...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61K49/00A61P1/00
Inventor 金丽华朱彩霞关法春兰小中
Owner NORTHEAST FORESTRY UNIVERSITY
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