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Preparation method of Kongray extract and its application in alcoholic liver protection drugs

A technology of alcoholic liver and extract, which is applied in the direction of drug combination, pill delivery, digestive system, etc., to achieve the effect of enhancing activity and enhancing clearing ability

Active Publication Date: 2015-09-02
SHANDONG HAIYU BIOLOGICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of the ray extract and its application in the preparation of alcoholic liver injury protection drugs have not been reported so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0009] Step 1: Preparation of Kong Ray Extract

[0010] Cook the fresh ray, remove the fish meat, rinse the cartilage with water, mince, add NaOH solution according to the mass ratio of solid to liquid at 1:1.5, stir and extract for 4 hours, then adjust the pH to 6-7 with HCl, filter, and put in the filtrate Add NaOH to adjust pH=8.5-9.0, and add compound protease to hydrolyze for 4 h according to the mass ratio of feed liquid to compound protease 1000:1. Heat the hydrolyzate at 80°C for 30 min, add HCl to adjust pH=3, let it stand still, filter the upper layer solution with pumice, add NaOH to adjust pH=10.5, decolorize with hydrogen peroxide and filter, add HCl to the filtrate to adjust pH=7, decompress the filtrate Concentrate to a small volume and dry the precipitate to obtain the ray extract.

[0011] Step 2: preparation of preparation

[0012] (1) Preparation of the capsule preparation of the ray extract of the present invention

[0013] Weigh 100 mg of the ray extrac...

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PUM

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Abstract

A method for preparing the extract of Kong Ray and its application in the preparation of drugs for protecting alcoholic liver damage. Add NaOH solution at a ratio of 1:1 to 1.5, stir and extract for 4 h, then use HCl to adjust pH=6 to 7, filter, add NaOH to the filtrate to adjust pH=8.5 to 9.0, according to the mass ratio of feed liquid and composite protease 1000:1 Add complex protease hydrolysis for 4h. Heat the hydrolyzed solution at 80°C for 30 minutes, add HCl to adjust the pH=2, let it stand still, filter the upper layer solution with diatomaceous earth, add NaOH to adjust the pH=10.5, filter after hydrogen peroxide decolorization, add HCl to the filtrate to adjust the pH=7, and decompress the filtrate Concentrate to a small volume and dry the precipitate to obtain the ray extract. The ray extract of the invention can be used as a protective agent for alcoholic liver damage by enhancing the activity of antioxidant enzymes and enhancing the body's ability to remove peroxidation reaction products.

Description

technical field [0001] The invention relates to a preparation method of the ray extract and its application in the preparation of protective drugs against alcoholic liver damage. . Background technique [0002] At present, alcoholism and addiction have become a global problem. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the liver. Chronic alcoholism can lead to symptoms such as alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis, fibrosis, and in severe cases, canceration. At present, for the treatment of alcoholic liver poisoning, many methods include amino acid and glucose infusion, multivitamins, maintenance of water, electrolyte and acid-base balance, etc. In recent years, many researchers have tried to find a method that can effectively prevent and protect the liver from Medicines that lessen the damaging effects of alcohol on the liver. [0003] Kong ray (Raja porosa Günther), commonly known as Laoban f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/60A61K9/48A61K9/20A61P1/16
Inventor 高华刘坤石振艳
Owner SHANDONG HAIYU BIOLOGICAL CO LTD
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