Thermo-sensitive gel composition and application thereof

Abstract

The invention relates to a thermo-sensitive gel composition. The composition comprises poloxamer segmented copolymer and indocyanine green. A thermo-sensitive gel water solution prepared from the thermo-sensitive gel can be prepared into an intravascular marked disrupting agent which has an excellent bio-compatibility and no toxic or side effect, can temporarily disrupt a target hepatic segment portal venous flow and realize accurate location of hepatic segment and blood vessels. The preparation can be used in clinical application of surgical operations, enables a resection part to be easily identified in an operation while performing disruption, realizes accurate location of the operation, and can greatly reduce the bleeding amount, so that a doctor can complete a resection operation more easily and more safely by means of the preparation, and the operation safety can be improved. The composition is arranged in a kit for preparing the thermo-sensitive gel water solution, can be stored and transported conveniently, and can be used for conveniently preparing the marked disrupting agent for surgical operations. The kit is easy to operate, low in cost and safe and convenient to use.

Description

technical field [0001] The invention belongs to the technical field of thermosensitive gel preparation and its medical application, and in particular relates to a thermosensitive gel composition and its application in surgery. Background technique [0002] At present, surgery has entered the "precision" era. An ideal liver cancer resection should not only completely remove the lesion, but also remove the liver segment where the lesion is located. However, the appearance of the human liver is a whole solid organ, which can be artificially divided into 8 segments according to its internal vascular distribution and blood supply. In order to accurately delineate the boundary of a certain liver segment during the operation, there are currently three commonly used clinical methods: (1) by combining liver surface anatomical landmarks and intraoperative ultrasound tracking The projection of the hepatic vein and portal vein branches on the liver surface determines the boundary of th...

AI Technical Summary

Problems solved by technology

The fly in the ointment of this method is that although the goal of accurately demarcating the boundaries of liver segments has been achieved, it is still necessary to use the Pringle method to block the first hepatic hilum when cutting the liver parenchyma, which will inevitably cause ischemia-reperfusion injury to the liver.

All of the above methods have disadvantages such as complex operation, high risk, or high price. Therefore, many surgeons still perform inaccurate "local excision" when performing liver resection.

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