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Application of Dioscorea nipponica total saponins in preparation of medicines for treatment of diabetes mellitus and complications of diabetes mellitus

A diabetes drug, diabetes technology, applied in drug combination, urinary system diseases, metabolic diseases, etc., can solve problems such as no research reports on total saponins of pangolinus

Inactive Publication Date: 2014-02-19
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no research report on pangolin total saponins in the preparation of drugs for the treatment of diabetes and its complications.

Method used

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  • Application of Dioscorea nipponica total saponins in preparation of medicines for treatment of diabetes mellitus and complications of diabetes mellitus
  • Application of Dioscorea nipponica total saponins in preparation of medicines for treatment of diabetes mellitus and complications of diabetes mellitus
  • Application of Dioscorea nipponica total saponins in preparation of medicines for treatment of diabetes mellitus and complications of diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] 1. Effects of total saponins of pangolinus on acute hyperglycemia mice

[0013] Sixty KM mice were randomly divided into 6 groups after being fed for one week: blank control group (i.g. 0.5% (w / v) CMC-Na), model group (i.g. 0.5% (w / v) CMC-Na), high Dose group (i.g. pangolin total saponins suspension (panshan dragon total saponins dissolved in 0.5% (w / v) CMC-Na) 300 mg / kg), medium dose group (i.g. pangolin total saponins suspension 150 mg / kg), Low-dose group (i.g. pangolin total saponins suspension 75 mg / kg) and positive control group (i.g. glibenclamide suspension 15 mg / kg). Gastrointestinal administration was performed once a day for 7 consecutive days, and mice were given 2 g / kg glucose solution (0.2 g / ml) after overnight fasting. Half an hour later, the blood was taken from the orbit, and the blood was centrifuged at 4°C and 1000 g for 10 min, and the serum was separated, and the glucose content in the serum was measured according to the instructions of the glucose...

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Abstract

The invention discovers that the Dioscorea nipponica total saponins have a remarkable function of improving insulin resistance, reducing blood sugar content of hyperglycemia model and increasing hepatic glycogen / muscle glycogen content of the same, and regulating glucose and lipid metabolism disorder; and the invention discloses an application of Dioscorea nipponica total saponins in preparation of medicines for treatment of diabetes mellitus and complications of the diabetes mellitus, especially an application in preparation of medicines for treatment of acute hyperglycemia, diabetes mellitus II or hereditary diabetes mellitus, and an application in preparation of medicines for treatment of diabetes mellitus induced osteoporosis or preparation of medicines for treatment of diabetes mellitus induced kidney function decrease.

Description

technical field [0001] The invention relates to a new application of active ingredients of traditional Chinese medicine, in particular to the application of total saponins of Pangosia pangolins extracted from Pangosia pangolins in the preparation of medicines for treating diabetes and its complications. Background technique [0002] Diabetes is a metabolic disorder that threatens the health of all human beings. It has a long course of disease, and if it is not well controlled for a long time, it is easy to combine with various complications. Diabetes complications almost involve every organ of the human body. source of disease". Chemically synthesized drugs have many deficiencies in the treatment of diabetes and its complications, while traditional Chinese medicine and its active ingredients have a significant therapeutic effect on diabetes and its complications. [0003] Panshanosaurus belongs to Dioscoreaceae ( Dioscoreaceae ) plant Dioscorea chinensis ( Discorea nippo...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/10A61P19/10A61P13/12A61K125/00
Inventor 彭金咏尹连红郑玲俐于浩董得时刘克辛许丽娜齐艳许有威
Owner DALIAN MEDICAL UNIVERSITY