Rabbit serum immunoglobulin liquid-phase suspension chips and preparation and application thereof

An immunoglobulin and suspension chip technology, which is applied in the field of IgG, rabbit serum immunoglobulin IgM, and IgA liquid phase suspension chips, can solve problems such as unavailable, limited detection of rats and mice, and application limitations of liquid phase chip technology.
CN103698534AInactive Publication Date: 2014-04-02ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG CHINESE MEDICAL UNIVERSITY
Publication Date
2014-04-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of biology, and particularly relates to rabbit serum immunoglobulin IgM, IgG and IgA liquid-phase suspension chips and a preparation and application thereof. The rabbit serum immunoglobulin liquid-phase suspension chips comprise 42#, 48# and 57# microspheres which are respectively coupled to IgG, IgM and IgA capture antibodies. In addition, the rabbit IgM, IgG and IgA liquid-phase chips are prepared by the method, the IgM, IgG and IgA contents in WHBE (White Hair and Black Eyes) rabbit and JW rabbit are synchronous detected, and a method for detecting the rabbit serum immunoglobulin IgM, IgG and IgA liquid-phase suspension chips is built. The method for detecting the rabbit serum immunoglobulin IgM, IgG and IgA liquid-phase suspension chips can be applied to research and development of immunology and a biological diagnostic kit, and experimental materials and new resources are provided for development of the bioengineering and pharmaceutical industry, especially research and development and production of biological diagnostic reagents.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a rabbit serum immunoglobulin IgM, IgG and IgA liquid-phase suspension chip and its preparation and application. Background technique

[0002] Experimental rabbits are currently one of the most commonly used experimental animals in the field of biomedical product development and medical science research, especially in the preparation of biological antibodies, ophthalmic surgery research, etc., playing an incomparable advantage over rats and mice. The level of serum immunoglobulin Ig is an important indicator to reflect the immune status of the animal body. The change of Ig content is closely related to the disease. Among them, IgG, IgM and IgA are the main effector molecules mediating humoral immunity.

[0003] Liquid phase suspension chip technology is a new type of chip technology that can simultaneously perform qualitative and quantitative analysis of multiple indicators. However,...

Claims

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