Taurine-containing ophthalmic in-vivo gel preparation and preparation method thereof

Abstract

The invention relates to a taurine-containing ophthalmic in-vivo gel preparation and a preparation method thereof. The taurine-containing ophthalmic gel is an ophthalmic preparation which is in a liquid state in vitro and forms a gel state after dropped into eyes. The taurine-containing ophthalmic gel is prepared by taking taurine as an active substance and supplementing a gel adjuvant, a thickening agent, a preservative, an osmotic-pressure conditioning agent, a pH conditioning agent and water for injection. The taurine-containing ophthalmic gel is suitable for treatment of diseases such as retinopathy and the like; and the ophthalmic gel is in the liquid state in vitro, a dosage is easy and accurate to control, the use is convenient, the ophthalmic gel can be uniformly spread after dropped into the eyes, gelates, is retained in the eyes for longer time and is not prone to loss, effective drug concentration can be effectively maintained, the treatment effect is enhanced, further, the toxicity is low, the irritation is small, the biocompatibility is good, and the taurine-containing ophthalmic gel is effective, facilitates clinical application, and has a wide development prospect.

Description

technical field [0001] The invention relates to ophthalmic in-body gel preparation of taurine, which belongs to the field of pharmaceutical preparations. Background technique [0002] Studies have shown that taurine has a certain therapeutic effect on various types of retinopathy. At present, the domestically marketed variety is taurine eye drops. After the eye drops are instilled into the eyes, they are easily diluted by tears and need to be used frequently. Although eye ointments and eye gels have a certain slow-release effect, they still exist Ophthalmic in-body gels, also known as in-situ gels, also known as instant gels, exist in the form of hydrophilic sols or macromolecular solutions in vitro. After dripping into the medication site, it will quickly gel to form a gel when encountering gel factors (temperature, body fluid, etc.), which not only retains the advantages of convenient administration and accurate dosage of the solution, but also has The site stays for a l...

AI Technical Summary

Problems solved by technology

At present, the domestically marketed variety is taurine eye drops. After the eye drops are instilled into the eyes, they are easily diluted by tears and need to be used frequently. Although eye ointments and ophthalmic gels have a certain slow-release effect, they exist Ophthalmic in-body gels, also known as in-situ gels, also known as instant gels, exist in the form of hydrophilic sols or macromolecular solutions in vitro. After being dripped into the medication site, it will quickly gel to form a gel when encountering gel factors (temperature, body fluid, etc.), which not only retains the advantages of convenient administration and accurate dosage of the solution, but also has the advantages of gel in the medication The site stays for a long time to achieve the purpose of long release and slow release

[0003] At present, there is no new drug variety of ophthalmic in-body gel on the market in China. The foreign FDA has approved one such product: Timolol Malaeate Ophthalmic Forming Solution (Timolol Malaeate Ophthalmic Forming Solution). The artificial tear ophthalmic in-body gel prepared by Sharm 407 has been launched in Australia and Japan

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