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Composition for common cold due to wind-cold

A technology for wind-cold cold and composition, which is applied to the application field of wind-cold and cold, and can solve the problems of high drug resistance, large toxic and side effects, and reducing the effect of relieving cough in children.

Inactive Publication Date: 2014-04-23
崔铠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Current central antitussives and peripheral antitussives, such as dextromethorphan, pentoxyverine, benproperine, and narcodine, all have side effects such as relatively large toxic and side effects and relatively high drug resistance. Due to the problem of taste, the anemofrigid cold for children does not have good palatability, thus reducing the effect of children's cough relief

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A composition for anemofrigid cold, made according to the following preparation method:

[0025] (1) Prepare seasoning base material from fish meat, set aside;

[0026] (2) Extract tangerine peel with 10 times the weight of ethanol, filter the extract, concentrate to a certain volume, pass through anion exchange resin, use 10 times the weight of 10% maleic acid solution as the eluent, concentrate the obtained eluent, and pass through D101 Macroporous adsorption resin, with 10 times the weight of 35% ethanol solution as eluent, the gained eluent is concentrated under reduced pressure to obtain tangerine peel alkaloids;

[0027] The extraction rate of alkaloid part is 6.51%, and 10g of crude drug is equivalent to 0.651g of alkaloid extract.

[0028] The above seasoning base material is mixed with the total alkaloids of tangerine peel in proportion to obtain the composition for anemofrigid cold.

[0029] A composition for wind-cold and common cold: the weight ratio of ...

Embodiment 2

[0037] A composition for anemofrigid cold, made according to the following preparation method:

[0038] (1) Prepare seasoning base material from fish meat, set aside;

[0039] (2) Extract tangerine peel with 10 times the weight of ethanol, filter the extract, concentrate to a certain volume, pass through anion exchange resin, use 15 times the weight of 15% maleic acid solution as the eluent, concentrate the obtained eluent, and pass through D101 Macroporous adsorption resin, with 10 times the weight of 40% ethanol solution as eluent, the gained eluent is concentrated under reduced pressure to obtain tangerine peel alkaloids;

[0040] The above seasoning base material is mixed with the total alkaloids of tangerine peel in proportion to obtain the composition for anemofrigid cold.

[0041] A composition for wind-cold and cold is characterized in that: the weight ratio of seasoning base material to total alkaloids of tangerine peel is 3:80.

[0042] A seasoning base material ...

Embodiment 3

[0048] Embodiment 3 Safety experiment

[0049] Test product: get each 1 kind of product of specific embodiment 1-2, grind into powder,

[0050] With the medicated powder of above-mentioned gained as test drug, take the Kunming kind of white mouse of body weight 18-20 gram of male and female each 30 as test animal, respectively gavage the medicine of different concentration, the dosage of each group of specific embodiment 1-3 is respectively It was 40mg / ml; the administration volume was 40ml / kg, and the mice were administered by intragastric administration 3 times a day, and the cumulative intragastric administration volume was 100ml / kg (the cumulative intragastric administration dose was 63.12g / kg). After 7 days of observation, no obvious toxic reaction and intestinal reaction of papaya were observed, and the maximum tolerated dose was greater than 63.12g / kg. After dissection, there was no obvious abnormality in the major organs.

[0051] Dilute the same test liquid with di...

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PUM

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Abstract

The invention relates to a composition for common cold due to wind-cold. The composition is prepared by adopting a following preparation method comprising the steps: preparing a seasoning base material from fish meat for later use; preparing pericarpium citri reticulatae total alkaloids, and mixing the seasoning base material with the pericarpium citri reticulatae total alkaloids according to a ratio to obtain the composition for common cold.

Description

technical field [0001] The invention relates to a composition for anemofrigid cold and its application in preparing anemofrigid cold for children. Background technique [0002] Coughing occurs after a cold or cold. As an important reflex protection mechanism, coughing can remove sputum or foreign objects in the respiratory tract, keep the respiratory tract clean and unobstructed, and prevent the formation of infection. Therefore, for mild and infrequent cough, as long as the sputum or foreign matter is removed, it can be relieved spontaneously, and there is no need to apply cough medicine. However, if the cough is severe and persists, it will not only aggravate the pain of the patient, affect rest and sleep, increase physical exertion, and even promote the development of the disease and produce other complications. Therefore, appropriate cough medicine should be used at the appropriate time to relieve the cough. [0003] From the perspective of modern medical theory, coug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P11/00A61P11/14A61P11/10A61K35/60
Inventor 崔铠李玲玲
Owner 崔铠