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Surface modification method for contact lens with medicine delivery

A contact lens and surface modification technology, which is applied in glasses/goggles, ophthalmic treatment, optics, etc., can solve the problems of limited loading, lack of ligands for contact lenses, and limited ability of contact lenses to control drug release. The effect of social and economic benefits

Inactive Publication Date: 2014-04-30
广州鲸盾网络科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug carrier, although contact lenses can prolong the residence time of drugs, control the release rate of drugs, and increase the use efficiency of drugs to a certain extent, the loading amount of drugs in contact lenses is limited to a certain extent. limited ability to interpret
In addition, contact lenses also lack ligands that interact with drugs

Method used

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  • Surface modification method for contact lens with medicine delivery
  • Surface modification method for contact lens with medicine delivery
  • Surface modification method for contact lens with medicine delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The polyelectrolyte PCM-β-CD and PEI were respectively formulated into 3mg / ml solutions, and then ofloxacin was dissolved in the PEI solution to obtain a final drug concentration of 1mg / ml. The contact lens is immersed in the PEI electrolyte solution containing the drug for 20 minutes, and then rinsed with 0.15M sodium chloride solution and blown dry after being taken out; the hydrogel sheet is put into the PCM-β-CD solution, soaked for 20 minutes, and then taken out with 0.15 Rinse with M sodium chloride solution and blow dry; repeat the above process until 20 layers are assembled.

Embodiment 2

[0034] The polyelectrolyte PCM-β-CD and CS were prepared into 1 mg / ml solutions, and ofloxacin was dissolved in the CS solution to obtain a final drug concentration of 1 mg / ml. The contact lens is immersed in the CS electrolyte solution containing the drug for 20 minutes, and then rinsed with 0.15M sodium chloride solution and blown dry after being taken out; the hydrogel sheet is put into the PCM-β-CD solution, soaked for 20 minutes, and taken out with 0.15 Rinse with M sodium chloride solution and blow dry; repeat the above process until 20 layers are assembled.

Embodiment 3

[0036] The polyelectrolyte PCM-β-CD and PEI were respectively formulated into 3mg / ml solutions, and then ofloxacin was dissolved in the PEI solution to obtain a final drug concentration of 1mg / ml. The contact lens is immersed in the PEI electrolyte solution containing the drug for 20 minutes, and then rinsed with 0.15M sodium chloride solution and blown dry after being taken out; the hydrogel sheet is put into the PCM-β-CD solution, soaked for 20 minutes, and then taken out with 0.15 Rinse with M sodium chloride solution and blow dry; repeat the above process until 10 layers are assembled.

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Abstract

The invention discloses a surface modification method for contact lenses with medicine delivery. The method comprises the following steps: dipping the contact lenses into a polycation electrolyte solution with medicines, soaking, then taking out, washing with a sodium chloride solution, and drying putting the obtained contact lenses into a polycarboxymethyl-beta-cyclodextrin, soaking, then taking out, washing with the sodium chloride solution and drying; repeating the two steps for the obtained contact lenses for 5-30 times so as to obtain the contact lenses with self-assembled multi-layer film surface modification layer to layer. The invention provides a surface coating of contact lenses with a good medicine release control capability, and a preparation method of the surface coating, the properties of an obtained product meet the basic requirements of cornea contact lenses, and release of eye medicines can be controlled. The surface modification method has great social and economic benefits.

Description

Technical field [0001] The invention belongs to the technical field of new materials, and specifically relates to the preparation of a surface coating of a contact lens. Background technique [0002] Contact lenses are a new type of material used for vision correction and beauty that appeared in the 1960s. There are two types of contact lenses currently on the market: hard lenses and soft lenses. Rigid lenses are mainly orthokeratology lenses, which are used for vision correction and the treatment of pseudomyopia. Soft lenses are hydrogel contact lenses, which are mainly used for vision correction and beauty (such as cosmetic lenses, etc.). In traditional hydrogel contact lenses, monomers are initiated by initiators, and the monomers undergo free radical copolymerization to form a hydrogel network. Common monomers for copolymerization of hydrogel contact lenses include hydroxyethyl methacrylate (HEMA), vinyl pyrrolidone (NVP), acrylamide (AA), methacrylic acid (MA) and other m...

Claims

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Application Information

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IPC IPC(8): C08J7/04C08L33/02A61F9/00G02C7/04
Inventor 胡小红董岩陈频王昕
Owner 广州鲸盾网络科技有限公司
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