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Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract with antitumor effect and application thereof

A technology for the anti-tumor effect of A. chinensis, applied in the directions of anti-tumor drugs, applications, medical preparations containing active ingredients, etc. Immunity, tumor growth inhibition, antioxidative enhancement effect

Inactive Publication Date: 2014-05-14
广西中医药大学附属瑞康医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no preparation technology for active extracts prepared from A. japonica as a raw material, and there is no report on the application of anti-tumor drugs or health care products using A. japonica as a main component.

Method used

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  • Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract with antitumor effect and application thereof
  • Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract with antitumor effect and application thereof
  • Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract with antitumor effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] An antitumor effect of the extract of Astragalus vulgaris was prepared by the following method:

[0020] Crush the dried Tonghui jade grass to a fine powder of 200 meshes, extract 3 times with 10 times the amount of water, filter, combine the extracts, concentrate the extracts to obtain the extract; suspend the extract with water, and apply the macroporous resin D101 chromatogram, wash with water and 50% ethanol in sequence; collect the 50% ethanol eluted fractions, recover the ethanol under reduced pressure, and dry under vacuum to obtain the anti-tumor effect of the extract of Euphorbia japonicus.

Embodiment 2

[0022] An antitumor effect of the extract of Astragalus vulgaris was prepared by the following method:

[0023] Crush the dried Tonghui jade grass to 200 mesh fine powder, extract 3 times with 5 times the amount of water, filter, combine the extracts, concentrate the extracts to obtain the extract; suspend the extract with water and apply the macroporous resin D101 chromatogram, wash with water and 100% ethanol in sequence; collect the 100% ethanol eluted fractions, recover the ethanol under reduced pressure, and dry under vacuum to obtain the anti-tumor effect of the extracts of Euphorbia japonica.

Embodiment 3

[0025] An antitumor effect of the extract of Astragalus vulgaris was prepared by the following method:

[0026] Crush the dried Tonghui jade grass to 200 mesh fine powder, extract 3 times with 10 water, filter, combine the extracts, concentrate the extracts to obtain the extract; suspend the extract with water, and chromatograph the macroporous resin D101 , Wash with water and 75% ethanol in sequence; collect the 50% ethanol eluted fractions, recover the ethanol under reduced pressure, and dry in vacuum to obtain the anti-tumor effect of the extract of the saccharum sibiricum.

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Abstract

The invention relates to a medicinal plant Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers, and particularly relates to a Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract and an application thereof. On the basis of the chemical composition and traditional efficacy studies of Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers, an active extract thereof is also prepared. Compared with the prior art, the invention proposes that the Pratia begonafolia (Wall) Lindl. or P. nummularia (Lam.)A.Br.et Aschers extract can resist tumor proliferation of H22 tumor-bearing mice, enhance immunity and enhance oxidation resistance and indicate that the active extract has a distinct inhibitory effect on tumor growth.

Description

Technical field [0001] The present invention relates to a medicinal plant Pratia begonafolia (Wall) Lindl.or P.nummularia (Lam.)A.Br.et Aschers], in particular to an extract of Pratia begonafolia (Wall) Lindl.or P.nummularia (Lam.)A.Br.et Aschers] and its application . Background technique [0002] Tumor is one of the most common diseases worldwide. Most patients are already at an advanced stage of cancer when they are diagnosed. The current treatment is a comprehensive three-dimensional therapy combining surgery, chemotherapy and radiotherapy, in order to reduce the incidence of tumor multidrug resistance. At present, anti-tumor drugs kill normal cancer cells and also destroy the body's immune function, causing serious side effects. [0003] Studies have found that a variety of botanicals have obvious anti-tumor effects, such as ginseng, Ligustrum lucidum, Asparagus, etc. P. nummularia (Pratia begonafolia (Wall) Lindl.or P.nummularia (Lam.)A), also known as small copper hammer, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/34A23L1/29A61P35/00A23L33/00
Inventor 赵立春
Owner 广西中医药大学附属瑞康医院
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