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Application of sodium carboxymethyl cellulose in chicken coccidiosis live oocyst vaccine

A technology of sodium carboxymethyl cellulose and chicken coccidiosis, which is applied in the field of immunobiology, can solve the problems of immune failure and uneven immunity.

Active Publication Date: 2014-05-14
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most widely used clinically is the drinking water immunization method, but the specific gravity of chicken coccidia oocysts is greater than that of water, and the vaccine oocysts are resuspended in water and soon precipitated to the bottom of the water, which is very easy to cause uneven immunity during the immunization process and lead to immunization failure

Method used

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  • Application of sodium carboxymethyl cellulose in chicken coccidiosis live oocyst vaccine
  • Application of sodium carboxymethyl cellulose in chicken coccidiosis live oocyst vaccine
  • Application of sodium carboxymethyl cellulose in chicken coccidiosis live oocyst vaccine

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of chicken coccidia live oocyst vaccine suspension solution

[0023] Prepare 0, 1%, 2%, 3%, 4%, and 5% sodium carboxymethylcellulose solutions of 100 mL each, and mix them with 1 bottle of chicken tender, heap type, giant, and poisonous Eimeria quadruple pentavalent The live vaccine (1000 feathers / bottle) was mixed thoroughly, and then 4L of distilled water was added to prepare a coccidiosis vaccine suspension solution, which was then divided into 3 groups, placed in 2L beakers, and left to stand. After standing still for 0 to 8 hours, use a pipette to draw 50 μL of vaccine suspension solution at the 400mL, 800mL and 1.2L scales of the beaker every two hours, count under the microscope with a hemocytometer, and find three scales at the same time for three groups The average number of total oocysts in the oocyst solution, taking 0h as the base, calculate the relative oocyst ratios in other time periods (the average total number of oocysts at...

Embodiment 2

[0027] Embodiment 2: The immune effect of sodium carboxymethyl cellulose solution to chicken coccidia live oocyst vaccine

[0028] Take 2% sodium carboxymethylcellulose as an example to illustrate its influence on the immune effect. Those skilled in the art will understand that other concentrations are also feasible.

[0029] 50 1-day-old chicks were raised in a coccidia-free environment, and 3-day-old chicks were divided into 5 groups as shown in Table 2, with 10 chickens in each group. Groups 1 to 3 were immunized according to the design in Table 1. Orally vaccinated with 1 portion of chicken tender, stacked, giant and poisonous Eimeria quadruple live oocyst vaccines, and groups 4 and 5 were not vaccinated as blank and control respectively. Groups were reared on flat ground (add litter to the ground).

[0030] The challenge test was carried out 21 days after inoculation, and all test chickens except the blank group were orally administered with Eimeria tenella HZ strain, E...

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Abstract

The invention discloses an application of sodium carboxymethyl cellulose in chicken coccidiosis live oocyst vaccine. The application comprises a step of uniformly mixing a sodium carboxymethyl cellulose solution with the chicken coccidiosis live oocyst vaccine. By adding the sodium carboxymethyl cellulose solution into the traditional chicken coccidiosis live oocyst vaccine, the chicken coccidiosis oocyst can be kept not to be settled in the water solution for a long time, side effects of the vaccine immunity are reduced and the immune effect of the chicken coccidiosis vaccine is obviously improved.

Description

technical field [0001] The invention relates to the application of sodium carboxymethylcellulose in chicken coccidia live oocyst vaccine and chicken coccidia live oocyst vaccine solution based on the application, belonging to the field of immunobiology. Background technique [0002] Chicken coccidiosis is a parasitic disease that seriously harms the intensive chicken industry and is prevalent worldwide. In the absence of preventive measures or prevention failures (such as drug ineffective due to drug resistance problems), the incidence of chickens can reach 30%-100%, the lethal rate can be as high as 80%, bringing huge economic losses to the chicken industry. [0003] For this disease, for a long time this field mainly prevents by adding anticoccidiostats in the feed. With the long-term use of anticoccidial drugs, chicken coccidia have developed extensive drug resistance, making their preventive effects worse and worse. At the same time, drug residues in chickens have becom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K39/012A61P33/02
Inventor 戚南山
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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