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A kind of nano silver used for antibacterial dressing and preparation method

A nano-silver, green synthesis technology, applied in nanotechnology, medical science, bandages, etc.

Active Publication Date: 2016-02-24
NANKAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Modern studies have shown that roselle is rich in protein, organic acids, vitamin C, sugars, various amino acids, a large number of natural pigments, etc., and the reducing sugars, citric acid, and vitamin C contained in it can reduce silver ions to nano Silver particles, and roselle is a green raw material that is non-toxic, harmless and beneficial to the human body. Using roselle as a reducing agent to prepare nano-silver has not been reported yet.

Method used

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  • A kind of nano silver used for antibacterial dressing and preparation method
  • A kind of nano silver used for antibacterial dressing and preparation method
  • A kind of nano silver used for antibacterial dressing and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0043] (1) Add 1.0360 g of roselle to 26.03 g of medical purified water, stir at 70°C for 8 hours, stop stirring and cool to room temperature, then filter the obtained mixture with a 0.22 μm filter membrane to obtain Roselle extract A;

[0044] (2) Mix 3.4951g of pharmaceutical grade polyethylene glycol-400 and 0.7080g of medical glycerin under stirring at room temperature to obtain Dispersant B;

[0045] (3) After uniformly mixing Roselle extract A and dispersant B at room temperature, place it at 80°C and stir for 8 hours, then cool to room temperature, and then use citric acid-sodium citrate buffer solution to adjust the pH value of the solution to 4.4, Obtain solution C;

[0046] (4) Dissolve 0.0630g silver nitrate in 3.8531g medical purified water at normal temperature, and obtain solution D after completely dissolving;

[0047] (5) Under ultrasonic conditions at 40°C, add solution D to solution C at a rate of 2.0mL / min, then continue to sonicate for 10min, then transfer...

Embodiment 2

[0050] (1) Add 1.0360 g of roselle to 26.03 g of medical purified water, stir at 70°C for 8 hours, stop stirring and cool to room temperature, then filter the obtained mixture with a 0.22 μm filter membrane to obtain Roselle extract A;

[0051] (2) Mix 3.4951g of pharmaceutical grade polyethylene glycol-400 and 0.7080g of medical glycerin under stirring at room temperature to obtain Dispersant B;

[0052] (3) After uniformly mixing Roselle extract A and dispersant B at room temperature, place it at 80°C and stir for 8 hours, then cool to room temperature, and then use citric acid-sodium citrate buffer solution to adjust the pH value of the solution to 4.4, Obtain solution C;

[0053] (4) Dissolve 0.0630g silver nitrate in 3.8531g medical purified water at normal temperature, and obtain solution D after completely dissolving;

[0054] (5) Add solution D to solution C at a rate of 0.5mL / min at room temperature, stir for 30 minutes, then transfer to a hydrothermal reaction kettl...

Embodiment 3

[0057] (1) Add 1.0360g of roselle to 26.03g of medical purified water, stir at 70°C for 8h, stop stirring and cool to room temperature, then filter the resulting mixture with a 0.22μm filter membrane to obtain Roselle extract A ;

[0058] (2) Mix 3.4951g of pharmaceutical grade polyethylene glycol-400 and 0.7080g of medical glycerin under normal temperature stirring to obtain Dispersant B;

[0059] (3) After uniformly mixing roselle extract A and dispersant B at room temperature, place it at 80°C and stir for 8 hours, then cool to room temperature, and then adjust the pH value to 4.4 with citric acid-sodium citrate buffer solution to obtain Solution C;

[0060] (4) Dissolve 0.0630g silver nitrate in 3.8531g medical purified water at normal temperature, and obtain solution D after completely dissolving;

[0061] (5) Add solution D to solution C at a rate of 0.2mL / min at room temperature, stir for 30 minutes and place in a microwave reactor at a reaction temperature of 60°C, a...

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Abstract

The invention provides nano-silver used for an anti-microbial dressing and a preparation method of the nano-silver. In the method, a roselle extracting solution serves as a reducing agent and pharmaceutical-grade polyethylene glycol and medical glycerinum serve as dispersing agents to compound nano-silver. The method includes the following steps that firstly, roselle is processed; secondly, the dispersing agents are prepared; thirdly, a nano-silver solution is prepared; fourthly, reactions are carried out in different reaction systems; fifthly, postprocessing is carried out, and the nano-silver anti-microbial dressing is prepared with the nano-sliver as an anti-microbial agent, at least one of borneol and mirabilite as filling agents, the medical glycerinum as a humidity-keeping agent, medical purified water as a solvent and the pharmaceutical-grade polyethylene glycol as a viscosity adjustment agent. Anti-microbial performance detection results indicate that the nano-silver dressing has very good anti-microbial performance and can be directly applied to the field of medicine.

Description

technical field [0001] The invention provides nano-silver used for antibacterial dressings and a preparation method thereof, which belongs to the technical field of synthesis of medical antibacterial nano-functional materials and a preparation process of antibacterial dressings containing nano-silver. Using roselle extract as reducing agent, pharmaceutical grade polyethylene glycol and medical glycerin as dispersant, and soluble silver salt as silver source, nano-silver with a particle size of 5-90nm was synthesized. Using nano-silver as antibacterial agent, one or two of borneol and thenardite as filler, medical glycerin as humectant, and pharmaceutical grade polyethylene glycol as viscosity regulator, the nano-silver antibacterial dressing was obtained. Background technique [0002] Nanosilver is currently one of the most commercialized materials and is used in more than 200 consumer products. As an antibacterial agent, a very small amount of nano-silver can produce a str...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00A61L15/44A61L15/42A61L15/18A61L15/20A61L15/26
Inventor 李伟夏婵婵龙本威关庆鑫刘向兰龚力平汤秀珍
Owner NANKAI UNIV