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Pharmaceutical composition comprising hydroxyethyl starch and electrolyte solution containing bicarbonate ions

A technology of bicarbonate ion and hydroxyethyl starch, which is used in drug combinations, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as incomplete metabolism and interference with test results.

Active Publication Date: 2015-11-25
JIANGSU HENGRUI MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in Ringer's acetate solution: the metabolism of acetic acid in patients with diabetic ketoacidosis and liver resection will be reduced by 1 / 3, and the metabolism is incomplete; In addition, the intravenous infusion of Ringer's acetate will interfere with the detection results of invasive aspergillosis enzyme-linked immunoassay, so it is contraindicated for patients with blood diseases and tumors who have the risk of aspergillus infection and sepsis to avoid diagnostic errors

Method used

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  • Pharmaceutical composition comprising hydroxyethyl starch and electrolyte solution containing bicarbonate ions
  • Pharmaceutical composition comprising hydroxyethyl starch and electrolyte solution containing bicarbonate ions
  • Pharmaceutical composition comprising hydroxyethyl starch and electrolyte solution containing bicarbonate ions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] prescription

[0030]

[0031] preparation:

[0032] Take an appropriate amount of water for injection, add the prescribed amount of hydroxyethyl starch, sodium chloride, potassium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate, sodium citrate dihydrate, citric acid monohydrate, stir to dissolve, and cool , add the prescribed amount of sodium bicarbonate, stir to dissolve, measure the pH value to 7.4, add water for injection to the total volume, stir evenly, filter, pot, sterilize under the protection of carbon dioxide, add outer bag packaging, and get ready.

Embodiment 2

[0034] prescription

[0035]

[0036] preparation:

[0037] Take an appropriate amount of water for injection, add the prescribed amount of hydroxyethyl starch, sodium chloride, potassium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate, sodium citrate dihydrate, citric acid monohydrate, stir to dissolve, and cool , add the prescribed amount of sodium bicarbonate, stir to dissolve, measure the pH value to 7.3, add water for injection to the total volume, stir evenly, filter, pot, sterilize under the protection of carbon dioxide, add outer bag packaging, and get ready.

Embodiment 3

[0039] prescription

[0040]

[0041]

[0042] preparation:

[0043] Take an appropriate amount of water for injection, add the prescribed amount of hydroxyethyl starch, sodium chloride, potassium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate, sodium citrate dihydrate, citric acid monohydrate, stir to dissolve, and cool , add the prescribed amount of sodium bicarbonate, stir to dissolve, measure the pH value to 7.2, add water for injection to the total volume, stir evenly, filter, pot, sterilize under the protection of carbon dioxide, add outer bag packaging, and get ready.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing hydroxyethyl starch and an electrolyte solution containing bicarbonate ions, and application thereof in preparation of a medicine for expanding blood volume. The side effect of hydroxyethyl starch injection prepared in the prior art is reduced by combining the electrolyte solution containing the bicarbonate ions with the hydroxyethyl starch, and a good effect of expanding the blood volume can be obtained.

Description

technical field [0001] The invention relates to a pharmaceutical composition comprising hydroxyethyl starch and an electrolyte solution containing bicarbonate ions and its application in the preparation of medicines for expanding blood volume. Background technique [0002] Surgical blood loss and trauma are the main indications for blood transfusion, but first giving colloid or crystalloid fluid (ie, fluid therapy) to patients with blood loss can reduce or avoid blood transfusion. In the past ten years, fluid therapy has developed rapidly. Liquid therapy includes two types of crystalloid and colloid. The diameter of solute molecules or ions in crystalloid is <1nm, such as normal saline, glucose solution, lactated Ringer’s solution, etc. Its main function is to restore extracellular fluid volume and maintain electrolyte balance . Colloidal fluid refers to the liquid whose solute molecular diameter is >1nm, or which can reflect the transmitted light beam, such as albumi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61P7/08A61K31/718A61K33/06A61K33/00A61K31/194
Inventor 周李云廖晓军吴玉霞
Owner JIANGSU HENGRUI MEDICINE CO LTD
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