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A multi-channel independent control integrated microfluidic chip based on thin-film acoustic wave device

A technology of microfluidic chip and thin-film acoustic wave, which is applied in the direction of analyzing fluid, laboratory utensils, chemical instruments and methods by using sound wave/ultrasonic wave/infrasonic wave, etc. Complicated, costly to resolve effects

Active Publication Date: 2016-05-25
SUZHOU INST OF BIOMEDICAL ENG & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the integrated system is extremely easy to cause pollution. After each measurement is completed, the sample chamber and the microchannel system must be cleaned, especially for the testing of multiple markers. The process is very cumbersome
The use of disposable polymer microfluidic chips is a common practice at present, but with the existing micro-processing technology, the process of processing an integrated microfluidic chip is relatively complicated and the cost is relatively high, and the cost of disposable chips is relatively high.

Method used

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  • A multi-channel independent control integrated microfluidic chip based on thin-film acoustic wave device
  • A multi-channel independent control integrated microfluidic chip based on thin-film acoustic wave device
  • A multi-channel independent control integrated microfluidic chip based on thin-film acoustic wave device

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Embodiment Construction

[0036] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0037] see figure 1 As shown, a multi-channel independent control integrated microfluidic chip based on a thin film acoustic wave device includes an upper cover sheet 1 and a lower substrate 8, and the cover sheet 1 is integrated with a sample chamber 2, a liquid storage tank 7, a thin film acoustic wave The fixed groove of the sensor 5, the microvalve switch structure and the microcolumn positioning structure 6, the microchannel is formed on the substrate 8, and the microvalve switch structure is composed of a valve membrane 4 and a valve cavity 1-1, and the valve membrane 4 is pressed by the microvalve switch fixing device 3, and the microvalve switch fixing device 3 is accurately positioned by the microcolumn positioning structure 6.

[0038] Further, the thin film acoustic wave sensor 5 is placed in the groove, and the thin film...

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Abstract

The invention discloses a multi-channel independent control integrated micro-fluidic chip based on a thin film acoustic wave device. The multi-channel independent control integrated micro-fluidic chip comprises an upper-layer cover sheet and a lower-layer substrate, wherein the upper-layer cover sheet is integrated with a sample chamber, a liquid storage tank, a fixing groove of a thin film acoustic wave sensor, a micro-valve switch structure and a micro-column positioning structure; microchannels are molded on the substrate; the micro-valve switch structure is composed of a valve film and a valve cavity; the valve film is pressed by a micro-valve switch fixing device and the micro-valve switch fixing device is accurately positioned by the micro-column positioning structure. With the adoption of the plurality of micro-channels, a plurality of markers in small-type samples are subjected to high flux determination; each micro-channel independently controls a micro-valve switch to obtain detection results of the sample under different use amounts and different determination time; the detection precision of pg / mL is realized by using the thin film acoustic wave sensor; the washing of a system can be automatically carried out so that the multi-channel independent control integrated micro-fluidic chip is repeatedly utilized and the problems of the integrated micro-fluidic chip that the process is complicated and the cost is high are effectively solved.

Description

technical field [0001] The invention belongs to the field of microfluidic chips, in particular to a multi-channel independent control integrated microfluidic chip based on a thin film acoustic wave device. Background technique [0002] During the occurrence of tumors, the increase of certain tumor markers in serum is closely related to tumors. Therefore, the detection of tumor markers plays an important role in the screening, diagnosis and prognosis of tumors. In order to achieve early diagnosis and treatment of tumors, most of the current research focuses on the detection of a tumor marker in living cells, which may bring "false positive" results. Because some tumor markers are expressed not only in cancer cells, but also in normal cells, it is of great significance to simultaneously detect multiple tumor markers in living cells. For example, liver cancer usually requires simultaneous detection of carcinoembryonic antigen (CEA), carbohydrate antigen 19 (CA19-9), alpha-fet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N29/02B01L3/00
Inventor 李传宇周连群吴一辉黎海文
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH
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