Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer

A technology of polydioxanone and polyvinylpyrrolidone is applied in the field of biodegradable polymer material preparation, and achieves the effects of being easy to master and simple in preparation method

Inactive Publication Date: 2016-01-27
SHANDONG UNIV OF TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this double-graft copolymer has not been reported in the literature.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of Polypeptide-Polydioxanone Graft Copolymer

[0015] Add 8 grams of poly(γ-benzyl-L-glutamate) with a molecular weight of 30,000, 4.2 grams of polydioxanone monotetradecyl ether with a molecular weight of 1000, and 1.2 grams of Add 200 ml of 1,1,2-trichloroethane solvent to p-toluenesulfonic acid, stir and react at 55° C. for 3 days under an inert atmosphere, terminate the reaction, and obtain the target compound by filtration, dialysis, and drying.

[0016] 2) Synthesis of polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer:

[0017] Add 7 grams of polypeptide-polydioxanone graft copolymer, 1.6 grams of polyvinylpyrrolidone monododecyl ether and 1.11 grams of p-toluenesulfonic acid with a molecular weight of 500, and then add 140 ml 1,1,2-Trichloroethane solvent, under an inert atmosphere, stirred at 55°C for 3 days, terminated the reaction, and then filtered, dialyzed, and dried to obtain the target product.

[0018] After testing: th...

Embodiment 2

[0020] 1) Synthesis of Polypeptide-Polydioxanone Graft Copolymer

[0021] Add 8 grams of poly(γ-ethyl-L-glutamate) with a molecular weight of 40,000, 6.1 grams of polydioxanone monotetradecyl ether with a molecular weight of 1500, and 1.3 grams of para Toluenesulfonic acid and 180 ml of dimethyl sulfoxide solvent were stirred and reacted at 56° C. for 4 days under an inert atmosphere, and the reaction was terminated, followed by filtration, dialysis, and drying to obtain the target compound.

[0022] 2) Synthesis of polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer:

[0023] Add 7 grams of polypeptide-polydioxanone graft copolymer, 1.8 grams of polyvinylpyrrolidone monododecyl ether and 0.92 grams of p-toluenesulfonic acid with a molecular weight of 600, and then add 130 ml Dimethyl sulfoxide solvent, under an inert atmosphere, stirred and reacted at 56° C. for 4 days, terminated the reaction, and then filtered, dialyzed, and dried to obtain the target pro...

Embodiment 3

[0026] 1) Synthesis of Polypeptide-Polydioxanone Graft Copolymer

[0027] Add 9 grams of poly(γ-methyl-L-glutamate) with a molecular weight of 50,000, 8.8 grams of polydioxanone monotetradecyl ether with a molecular weight of 2000, and 1.35 grams of para Toluenesulfonic acid and 250 ml of 1,1,2-trichloroethane solvent were stirred and reacted at 58°C for 3 days under an inert atmosphere, and the reaction was terminated, followed by filtration, dialysis, and drying to obtain the target compound.

[0028] 2) Synthesis of Polypeptide-Polydioxanone-Polyvinylpyrrolidone Double Graft Copolymer

[0029] Add 8 grams of polypeptide-polydioxanone graft copolymer, 2.3 grams of polyvinylpyrrolidone monododecyl ether and 1.06 grams of p-toluenesulfonic acid with a molecular weight of 700, and then add 150 ml 1,1,2-Trichloroethane solvent, under an inert atmosphere, stirred and reacted at 58°C for 3 days, terminated the reaction, and then filtered, dialyzed, and dried to obtain the target ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
water absorptionaaaaaaaaaa
water absorptionaaaaaaaaaa
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer, which adopts the following steps: 1) synthesis of a polypeptide-polydioxanone graft copolymer : Add polypeptide homopolymer, polydioxanone monotetradecyl ether, solvent and catalyst in a dry reactor, under an inert atmosphere, stir and react at 55-58°C for 3-4 days to obtain the target product ; 2) Synthesis of polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer: add polypeptide-polydioxanone graft copolymer, catalyst, solvent and Polyvinylpyrrolidone monododecyl ether, under an inert atmosphere, stirred and reacted at 55-58°C for 3-4 days to obtain the target product of the present invention. The process of the invention is simple, and the obtained object is a novel degradable biological material.

Description

technical field [0001] The invention relates to a preparation method of a polypeptide-polydioxanone-polyvinylpyrrolidone double graft copolymer, which belongs to the technical field of preparation of biodegradable polymer materials. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability, which can be widely used in medicine as a carrier for the preparation of sustained-release drug systems; however, the polypeptide material is relatively hard and has poor hydrophilicity. As a result, its application is limited to a certain extent. Polydioxanone has better biocompatibility and biodegradability, and is relatively soft. Polyvinylpyrrolidone has excellent biocompatibility and biodegradability, and has good hydrophilicity. First graft the polydioxanone segment to the polypeptide molecular chain to obtain the polypeptide-polydioxanone graft copolymer, and then graft the polyvinylpyrrolidone segment to the polypeptide-poly On t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH