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Pharmaceutical composition for lowering urine protein and application of pharmaceutical composition

A composition and technology of urinary protein, applied in the field of pharmaceutical compositions for reducing urinary protein, can solve the problems of reducing the biological activity of urinary protein and not finding isoorientin, etc. The effect of urine

Inactive Publication Date: 2014-07-16
杨献华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] By searching the domestic and foreign literature, there is no literature report that isorientin has the biological activity of reducing urinary protein.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] Rat doxorubicin nephropathy is caused by doxorubicin and its metabolites directly damaging podocytes or making podocyte metabolism disorder, resulting in morphological changes in podocytes and changes in anion sites in the basement membrane, thereby causing glomerular The molecular and charge barriers of the filtration membrane are compromised, leading to the development of proteinuria. This model is similar to human minimal disease (MCD), and is a recognized minimal disease model at home and abroad. The following test examples of drug intervention in animal models further illustrate that isorientin has the biological activity of reducing urinary protein.

[0013] 40 healthy male SD rats, body weight 200-220g, were randomly divided into normal control group (10 rats), model control group (15 rats), and treatment group (15 rats); except for the normal control group, the other two groups of rats The tail vein injection of doxorubicin 4mg / kg (concentration of doxorubicin ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for lowering urine protein and an application of the pharmaceutical composition. The composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients include orientin and / or isoorientin. The pharmaceutical composition disclosed by the invention has the effect of lowering urine protein, and especially can be used for treating a nephrotic patient with minimal lesion.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for reducing urinary protein and its application. Background technique [0002] Proteinuria is directly related to renal pathological changes, which is not only the clinical manifestation of renal pathological degeneration, persistent proteinuria shows renal toxicity through different mechanisms, and accelerates the progression of kidney disease, not only accompanied by glomerular damage and normal glomerular permeability Loss of sex also leads to tubular cell inflammation and fibroblast response causing interstitial damage and fibrosis. The ultimate goal of treating kidney disease is to protect kidney function and inhibit the progressive development of kidney disease. Therefore, drugs that reduce proteinuria can slow down the progression of kidney disease and inhibit structural changes in the kidney, thereby reducing the clinical manife...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P13/12
Inventor 刘学键
Owner 杨献华
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