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A drug for the treatment of nephrotic syndrome

A technology for treating nephrotic syndrome and drugs, applied in the field of drugs for treating nephrotic syndrome, can solve problems such as severe adverse reactions, achieve the effects of reducing levels, inhibiting ear swelling, and increasing serum albumin levels

Active Publication Date: 2016-02-17
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine generally uses prednisone and other glucocorticoids for the treatment of this disease, but the adverse reactions of hormonal drugs are often more serious; and some patients transform into refractory nephrotic syndrome due to hormone resistance, hormone dependence or recurrent attacks

Method used

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  • A drug for the treatment of nephrotic syndrome
  • A drug for the treatment of nephrotic syndrome
  • A drug for the treatment of nephrotic syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 7 parts of Angelica, 2 parts of Tripterygium wilfordii, 15 parts of Poria cocos, 10 parts of raw land, 15 parts of Atractylodes macrocephala, and 4 parts of licorice.

[0011] Preparation method: Weigh each raw material according to parts by weight, crush it to 60 mesh, add 8 times the volume of 80% ethanol to soak for 10 hours, reflux extraction twice, each time for 1 hour, filter the alcohol extract, combine, and concentrate under reduced pressure to 50 ? The relative density at C is 1.12. The concentrated liquid is either mixed with pharmaceutical excipients according to conventional methods to make liquid oral preparations, or spray-dried and mixed with pharmaceutical excipients to make solid oral preparations.

Embodiment 2

[0013] 9 parts of Angelica, 3 parts of Tripterygium wilfordii, 12 parts of Poria cocos, 12 parts of raw land, 12 parts of Atractylodes macrocephala, and 6 parts of licorice.

[0014] Preparation method: Weigh each raw material by weight, crush it to 70 mesh, add 10 times the volume of 80% ethanol to soak for 10 hours, reflux extraction twice, each time for 1 hour, filter the alcohol extract, combine, and concentrate under reduced pressure to 55 ? The relative density at C is 1.12. The concentrated liquid is either mixed with pharmaceutical excipients according to conventional methods to make liquid oral preparations, or spray-dried and mixed with pharmaceutical excipients to make solid oral preparations.

Embodiment 3

[0016] 11 parts of Angelica, 4 parts of Tripterygium wilfordii, 10 parts of Poria cocos, 15 parts of raw land, 10 parts of Atractylodes macrocephala, and 8 parts of licorice.

[0017] Preparation method: Weigh each raw material according to parts by weight, crush it to 80 mesh, add 12 times the volume of 80% ethanol to soak for 10 hours, reflux extraction twice, each time for 1 hour, filter the alcohol extract, combine, and concentrate under reduced pressure to 60 ? The relative density at C is 1.12. The concentrated liquid is either mixed with pharmaceutical excipients according to conventional methods to make liquid oral preparations, or spray-dried and mixed with pharmaceutical excipients to make solid oral preparations.

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Abstract

The invention provides a medicament for treating a nephrotic syndrome. The medicament is prepared from the following raw materials in parts by weight: 5-15 parts of angelica, 1-5 parts of tripterygium wilfordii, 8-20 parts of poria cocos, 8-20 parts of rehmannia root, 8-20 parts of white atractylodes rhizome and 2-10 parts of licorice. The medicament can effectively reduce the 24h urine protein quantitation of a nephrotic syndrome model rat, significantly improve the content of serum albumin, reduce the levels of total cholesterol and triglyceride in rat serum of a model group and inhibit dimethylbenzene-induced ear swelling of mice, and has a good treatment effect on the nephrotic syndrome.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a medicine for treating nephrotic syndrome. Background technique [0002] Nephrotic syndrome (NS) refers to a group of syndromes caused by various etiologies and characterized by increased permeability of the glomerular basement membrane after damage. The clinical manifestations are massive proteinuria, hypoproteinemia, high Lipidemia and varying degrees of edema. Western medicine generally uses prednisone and other glucocorticoids for the treatment of this disease, but the adverse reactions of hormonal drugs are often more serious; and some patients transform into refractory nephrotic syndrome due to hormone resistance, hormone dependence or recurrent attacks. Contents of the invention [0003] In order to solve the above technical problems and to provide a traditional Chinese medicine preparation for treating nephrotic syndrome, the present invention provides a m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P13/12
Inventor 何昱石森林范永升王新昌
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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