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Method for preparing quercetin from rutin

A technology of quercetin and rutin, which is applied in the field of preparing quercetin from rutin, can solve the problems of low product purity, failure to meet international standards, lack of comprehensive utilization of resources, complex and cumbersome processes, etc., and achieve a complete hydrolysis reaction The effect of completeness, shortened production cycle, and simple product process

Inactive Publication Date: 2016-05-04
罗俊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of complex and cumbersome process, long reaction time, low product purity not up to international standards, pollution, and lack of comprehensive utilization of resources in existing methods for preparing quercetin, and to provide a method for using rutin Method for preparing quercetin

Method used

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  • Method for preparing quercetin from rutin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step a: Collect 10kg (wet weight) of Sophora japonica flower buds, steam the collected Sophora japonica flower buds in 100°C water vapor for 12 minutes to eliminate degradative enzymes, take out the steamed flower buds, dry them in the air, crush them, and infiltrate in turn, and use them for percolation A leaching solution containing 18% sodium carbonate, 20% sodium bisulfite, and 30% calcium chloride, the ratio of the leaching solution to Sophora japonica flower buds (wet weight) is 2.5L: 1kg, and the solution obtained after percolation is filtered to remove slag to obtain a crude extract.

[0023] Step b: Add the natural traditional Chinese medicine clarifier KBT-ZTC to the crude extract obtained in step a. The ratio of the flocculation clarifier to the crude extract is 3.0g:100L. After adding the flocculation clarifier, stir gently to make the flocculation clarifier Distribute evenly in the extract, and then let it stand for 25 minutes to precipitate impurities and ...

Embodiment 2

[0027] Step a: collect 10kg (wet weight) of Sophora japonica flower buds, steam the collected Sophora japonica flower buds in 120°C water vapor for 10 minutes to eliminate degradative enzymes, take out the steamed flower buds, dry them in sequence, crush them, and infiltrate them, and use them for percolation A leaching solution containing 15% sodium carbonate, 30% sodium bisulfite, and 40% calcium chloride, the ratio of the leaching solution to Sophora japonica buds (wet weight) is 3.0L: 1kg, and the solution obtained after percolation is filtered to remove slag to obtain a crude extract.

[0028] Step b: Add the natural traditional Chinese medicine clarifier KBT-ZTC to the crude extract obtained in step a, the ratio of the flocculation clarifier to the crude extract is 2.5g:100L, add the flocculation clarifier and stir gently to make the flocculation clarifier in the crude Distribute evenly in the extract, and then let it stand for 30 minutes to precipitate impurities and re...

Embodiment 3

[0031]Step a: Collect 10kg (wet weight) of Sophora japonica flower buds, steam the collected Sophora japonica flower buds in 115°C water vapor for 13 minutes to eliminate degrading enzymes, take out the steamed flower buds, dry them in the air, crush them, and infiltrate in turn, and use them for percolation A leaching solution containing 30% sodium carbonate, 15% sodium bisulfite, and 30% calcium chloride, the ratio of the leaching solution to Sophora japonica flower buds (wet weight) is 2.0L: 1kg, and the solution obtained after percolation is filtered to remove slag to obtain a crude extract.

[0032] Step b: Add the natural traditional Chinese medicine clarifier KBT-ZTC to the crude extract obtained in step a, the ratio of the flocculation clarifier to the crude extract is 5.0g:100L, add the flocculation clarifier and stir gently to make the flocculation clarifier in the crude Evenly distribute in the extract, and then stand still for 20 minutes to precipitate impurities a...

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Abstract

The invention belongs to the field of flavonoid compound extraction, and particularly relates to a method for preparing quercetin with rutin. The method comprises the steps that collected sophora flower buds are steamed through steam, aired, smashed and percolated, colloid and green element impurities are removed through flocculation clarification treatment, complexing treatment is protected through antioxygen and complexing agents, mixed acid is added to the sophora flower buds, the sophora flower buds are adjusted to be acidic, heating and pressurization are carried out, and the quercetin is obtained in a hydrolyzing mode. According to the method, in the middle later procedure of the process of extracting the rutin from the sophora flower buds, edulcoration treatment is directly carried out on the midbodies of the extracted rutin, the colloid, chlorophyll and other impurities in the rutin are removed, a filter pressing drying treatment procedure and a rutin crude product re-refining procedure are not needed, the technological process is shortened, production cost is lowered, the produced finished products are further hydrolyzed, the content reaches the international standard, and the quercetin content can reach more than 95 percent when detected through HPLC.

Description

technical field [0001] The invention belongs to the field of extraction of flavonoids, in particular to a method for preparing quercetin from rutin. Background technique [0002] Rutin is a kind of flavonoid compound, which is widely distributed in plants in nature, and exists in the roots, stems, leaves, flowers, fruits and seeds of many plants. Some commonly used traditional Chinese medicines, such as Sophora japonica, Rutaceae, Yangmai, Seabuckthorn, Ginkgo, Lycium barbarum, Motherwort, Bupleurum, Prunella vulgaris, Aloe, Eucalyptus leaves and tobacco leaves, etc. contain rutin. One of the important raw materials. [0003] Quercetin belongs to flavonoids and exists in the flowers, leaves and fruits of many plants, mostly in the form of glycosides, such as rutin (rutin), quercetin, hyperoside, etc., which can be obtained by acid hydrolysis quercetin. It has good pharmacological effects such as expectorant and cough, and has a certain antiasthmatic effect. In addition, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30
CPCC07D311/30C07D311/40
Inventor 罗俊
Owner 罗俊
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