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Compositions comprising maltotriose and methods of using same to inhibit damage caused by dehydration processes

A technology of maltotriose and composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, applications, etc., and can solve problems such as damage and oxidative stress

Inactive Publication Date: 2014-07-16
MJN U S HLDG LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, however, the dehydration process can potentially cause significant damage and oxidative stress to microbial cell membranes, lipids, proteins, and DNA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] This example illustrates nutritional compositions prepared according to the present disclosure.

[0057] A liquid composition of corn syrup solids was prepared and the corn syrup solids were enriched in maltotriose using the enzyme maltotriose forming alpha-amylase (Amano Enzyme Inc). After enrichment, approximately 45% by weight of the corn syrup solids contained maltotriose. Liquid compositions comprising maltotriose-enriched corn syrup solids The combination contains whey protein and casein, live Lactobacillus rhamnosus GG, fat blend, vitamin C, polyphenols in the proportions indicated in the table below and vitamin E liquid composition. The combined liquid composition is lyophilized into powder form. After 6 months of storage, the powder was reconstituted in water, and the cell membrane of Lactobacillus rhamnosus GG showed little oxidative stress and physical damage, and the lipid, protein and DNA of the microorganism also showed little oxidative stress and damag...

Embodiment 2

[0060] This example illustrates pharmaceutical compositions prepared according to the present disclosure.

[0061] A liquid composition comprising the ingredients mentioned below was prepared and then freeze-dried into a powder form. Most of the amino acids used have a negative overall charge at pH 7.0. After 6 months of storage, the powder was reconstituted in water, and human growth hormone showed little oxidative stress and physical damage.

[0062] Element weight percentage Maltotriose 40 % human growth hormone solution 10 % amino acid 10 % Vitamin C 0,5 % polyphenols 1 % Vitamin E 0,5 % other excipient solutions 38 %

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PUM

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Abstract

Compositions comprising maltotriose are disclosed herein. In certain embodiments, the compositions comprise maltotriose and at least one component whose function is subject to impairment by a dehydration process, such as a live microorganism. Methods for inhibiting damage caused by dehydration are also disclosed herein. In particular embodiments, the method includes preparing a composition comprising maltotriose and at least one component whose function is subject to impairment by a dehydration process and removing water from the composition by one or more dehydration processes.

Description

technical field [0001] The present invention generally relates to compositions comprising maltotriose and methods of inhibiting damage caused directly or indirectly by the dehydration process. Background technique [0002] Dehydration processes, such as spray drying and freeze drying, are used in many fields and have various benefits such as improved stability and improved storage and handling properties of materials. Despite these benefits, the dehydration process can cause significant damage. For example, it is often desirable to include live, beneficial microorganisms in frozen or spray-dried nutritional compositions for human use to promote the growth of beneficial microorganisms in the human intestinal tract. Unfortunately, however, the dehydration process can potentially cause significant damage and oxidative stress to microbial cell membranes, lipids, proteins, and DNA. Thus, when the composition is administered to humans, the viability of the microorganisms can be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L1/30C12N1/04A61K35/74A23L33/00A61K35/747
CPCA23L5/20A23L29/35A23L33/135A23L33/40A23V2002/00A61K35/745A61K35/747C12N1/04C12N1/20A23V2300/10A23V2250/5114A23V2200/3204A61K2300/00A23V2250/616A61P5/06
Inventor Z.敖J.M.冈萨雷斯B.J.泰勒
Owner MJN U S HLDG LLC
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