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Method used for preparing pharmaceutic adjuvant Eudragit RL100 polymer particulates

A technology of pharmaceutical excipients and polymers, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, block delivery, etc., to achieve stable and effective treatment of blood drug concentration, reduction of side effects, and easy control

Active Publication Date: 2014-07-23
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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  • Application Information

AI Technical Summary

Problems solved by technology

Among various microencapsulation technology methods, it is a new challenge to prepare drug particles with small particle size and uniform distribution

Method used

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  • Method used for preparing pharmaceutic adjuvant Eudragit RL100 polymer particulates
  • Method used for preparing pharmaceutic adjuvant Eudragit RL100 polymer particulates
  • Method used for preparing pharmaceutic adjuvant Eudragit RL100 polymer particulates

Examples

Experimental program
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Embodiment Construction

[0013] Preparation of Eudragit RL100 spherical microparticles.

[0014] This example is to prepare Eudragit RL100 polymer spherical particles by enhanced solution dispersion technology. Among them, the particle preparation device is an enhanced solution dispersion (SEDS) device, such as figure 1 as shown in a.

[0015] (1) First weigh 50mg of Eudragit RL100 and dissolve it in 10ml of N,N dimethylformamide solvent, then add a certain mass (117mg, 50mg, 22mg) of PVP to fully dissolve it.

[0016] (2) The temperature in the water bath is controlled by electric heating, accurate to ±0.1°C. CO provided by the cylinder 2 It is injected into the whole device through the plunger pump, and then the pressure of the system is controlled by the ISCO pump. After rising to the set pressure, it is accurate to ±0.1MPa, and the pressure and temperature of the device are stabilized for 30 minutes.

[0017] (3) Then, turn on and adjust the CO 2 With the outlet valve controlled by the ISCO p...

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Abstract

The invention discloses a method used for preparing pharmaceutic adjuvant Eudragit RL100 polymer particulates. According to the method, dispersant (A) polyvinylpyrrolidone is added into a (B) Eudragit RL100 polymer solution; strengthened solution dispersion is used for processing an obtained mixture so as to obtain the pharmaceutic adjuvant Eudragit RL100 polymer particulates. The method is suitable for preparing slow / controlled release particulate medicinal preparations. Method conditions used for preparing the pharmaceutic adjuvant slow release coating material Eudragit RL100 polymer particulates can be used for medicine micronization (encapsulation), increasing delivery approaches of medicines, reducing medicine side effect and medicine administration times, and increasing utilization ratio of medicines in biological bodies fully.

Description

technical field [0001] The invention relates to a method for preparing slow / controlled release coating material polymer particles (microcapsules or microspheres) in the field of medicine. Background technique [0002] The microencapsulation release system of drugs uses natural or synthetic pharmaceutical polymer materials as capsule materials, and disperses or encapsulates drugs in materials to form particles (microcapsules or microspheres), which can reduce or eliminate the effects of conventional drugs. It is an important way of sustained / controlled drug delivery due to side effects, instability of drug release, and patient discomfort. Compared with other sustained-release and controlled-release preparation technologies (such as matrix-type controlled-release tablets, coated sustained-release technology, osmotic pump preparations, etc.), the sustained / controlled release system of drug particles is easy to adhere to due to the small particle size of the drug particles , ca...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/32
Inventor 王辉李佳林尼尔福斯特
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
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