Pantoprazole sodium-containing enteric-coated tablet and preparation method thereof

A technology of pantoprazole sodium and enteric-coated tablets is applied in the field of enteric-coated tablets containing pantoprazole sodium and its preparation, which can solve the problems of unfavorable low-cost production and the like, and achieve few types of auxiliary materials, high preparation stability, Rapid drug release effect

Active Publication Date: 2014-07-23
LIAONING NIRVANA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pantoprazole sodium tablet contains multiple auxiliary materials ...

Method used

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  • Pantoprazole sodium-containing enteric-coated tablet and preparation method thereof
  • Pantoprazole sodium-containing enteric-coated tablet and preparation method thereof
  • Pantoprazole sodium-containing enteric-coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Tablet core prescription

[0023]

[0024] Gastric Coating Prescription

[0025]

[0026] Enteric Coating Prescription

[0027]

[0028] Preparation Process:

[0029] (1) The prescription quantity takes pantoprazole sodium, dissolves it in absolute ethanol, adds polacrilin potassium, dries at 40°C to remove ethanol, and the dry matter passes through a 60-mesh sieve, then mixes with lactose and magnesium stearate of the prescription quantity Uniform, tablet pressing, the pressing process was smooth, no sticking and punching, and the tablet core was obtained;

[0030] (2) Take hydroxypropyl methylcellulose as film-forming material, polyethylene glycol as plasticizer, talcum powder as anti-adhesive agent, water as dispersion medium, prepare coating solution, core tablet is wrapped with isolation coat, increase weight 5%;

[0031] (3) Using acrylic resin L100-55 as film-forming material, talcum powder as anti-adhesive agent, plasticizer as triethyl citrate, wat...

Embodiment 2

[0033] Tablet core prescription

[0034]

[0035]

[0036] Gastric Coating Prescription

[0037]

[0038] Enteric Coating Prescription

[0039]

[0040] Preparation Process:

[0041] (1) The prescription quantity takes pantoprazole sodium, is dissolved in absolute ethanol, adds polacrilin potassium, dries at 45 ℃ and removes ethanol, and the dry matter is crossed 60 mesh sieves, then with microcrystalline cellulose, stearin of prescription quantity Magnesium acid was mixed evenly, and tableted, no sticking and punching was seen, and the tablet core was obtained;

[0042] (2) Take hydroxypropyl methylcellulose as film-forming material, polyethylene glycol as plasticizer, talcum powder as anti-adhesive agent, water as dispersion medium, prepare coating solution, core tablet is wrapped with isolation coat, increase Weight 7%;

[0043] (3) Using acrylic resin L100-55 as film-forming material, talcum powder as anti-adhesive agent, plasticizer as triethyl citrate, wa...

Embodiment 3

[0045] Tablet core prescription

[0046]

[0047] Gastric Coating Prescription

[0048]

[0049]

[0050] Enteric Coating Prescription

[0051]

[0052] Preparation Process:

[0053] (1) prescription quantity takes pantoprazole sodium, dissolves in absolute ethanol, adds polacrilin potassium, dries at 40 DEG C and removes ethanol, and the dry thing crosses 60 mesh sieves, then microcrystalline cellulose, stearin with prescription quantity Magnesium acid was mixed evenly, and tableted, no sticking and punching was seen, and the tablet core was obtained;

[0054] (2) Take hydroxypropyl methylcellulose as film-forming material, polyethylene glycol as plasticizer, talcum powder as anti-adhesive agent, water as dispersion medium, prepare coating solution, core tablet is wrapped with isolation coat, increase Weight 6%;

[0055] (3) Using acrylic resin L100-55 as film-forming material, talcum powder as anti-adhesive agent, plasticizer as triethyl citrate, water as dis...

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PUM

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Abstract

The invention discloses a pantoprazole sodium-containing enteric-coated tablet and a preparation method thereof. The enteric-coated tablet is obtained by sequentially coating a tablet core with an isolating coating and an enteric coating, wherein the tablet core is formed by evenly mixing medicine-containing granules with a filler and a lubricant and then directly tabletting, and a preparation method of the medicine-containing granules comprises the following steps of: dissolving pantoprazole sodium into absolute ethyl alcohol, adding polacrilin potassium, drying and volatilizing to remove ethanol, and sieving dried materials. The varieties of auxiliary materials are fewer, the drug release is fast, the stability of the preparation is high, the production technology is simple, no sticking phenomenon exists in tabletting, and the industrial production is easy.

Description

technical field [0001] The invention belongs to the technical field of chemical preparations, and in particular relates to a solid oral preparation of pantoprazole sodium, in particular to an enteric-coated tablet containing pantoprazole sodium and a preparation method thereof. Background technique [0002] Pantoprazole sodium (PAZ-Na) is a new generation of proton pump inhibitors after omeprazole and lansoprazole. + / K + -ATPase inhibits gastric acid secretion, and mainly treats duodenal ulcer, gastric ulcer, Zoller's syndrome and reflux esophagitis. Pantoprazole is one of several common proton pump inhibitors (PPI) on the market at present, according to literature reports, the bioavailability of pantoprazole is 7 times higher than omeprazole, and the selectivity to parietal cells is more dedicated. Pantoprazole is a dialkoxypyridylbenzimidazole compound with good target specificity and acid stability, and daily oral standard dose (40mg) of pantoprazole can inhibit 98% o...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/4439A61K47/32A61P1/04
Inventor 严白双
Owner LIAONING NIRVANA PHARMA
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