Brain-tonifying capsule pharmaceutical composition, and preparation method thereof

A technology of Yinao capsules and compositions, applied in the field of Yinao capsule pharmaceutical compositions and their preparation, capable of solving problems such as application limitations of solid dispersion technology, low bioavailability, poor dissolution of preparations, etc., to overcome high drug loading Problems, promotion of human body absorption, effects of increasing dispersion and specific surface area

Inactive Publication Date: 2014-07-23
WUHU LUYE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 2. The preparation has poor dissolution rate and low bioavailability:
The application of solid dispersion technology to improve the dissolution rate of drugs and increase their bioavailability has become a hot spot in pharmaceutical research in recent years, but the amount of carriers used in the preparation of solid dispersions is large, and it is difficult to achieve high drug loading. The ratio of carrier to drug in the technology is usually greater than 2:1, so it is still difficult to apply this technology to large doses of drugs. Because traditional Chinese medicine prescriptions often have large doses, the application of solid dispersion technology in the field of traditional Chinese medicine is greatly restricted

Method used

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  • Brain-tonifying capsule pharmaceutical composition, and preparation method thereof
  • Brain-tonifying capsule pharmaceutical composition, and preparation method thereof
  • Brain-tonifying capsule pharmaceutical composition, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Yinao solid dispersion capsule

[0023] Weigh 38.6g tortoiseshell gum, 193.3g polygala, 387.3g keel, 387.3g ganoderma lucidum, 49.3g schisandra chinensis, 193.3g Ophiopogon japonicus, 193.3g Shichangpu, 111.0g codonopsis ginseng, 66.6g ginseng, 387.3g poria cocos, the above ten flavors, except In addition to tortoise shell glue, 25% of ginseng and Poria cocos are respectively crushed into fine powder, and the remaining Poria cocos and other seven flavors such as Polygala are decocted twice, the first time is 3 hours, the second time is 2 hours, filtered, and the filtrates are combined and concentrated into Thick paste, add ginseng, poria cocos fine powder and melted tortoise shell glue, mix well, dry, powder into fine powder, sieve for later use;

[0024] Weigh 2.19g of PEG6000605.11g, Poloxamer1881405.11g, mix with the fine powder of the active ingredient prepared above, heat and stir until completely melted, cool rapidly to solidify, pulverize, pass throu...

Embodiment 2

[0025] Embodiment 2 Yinao solid dispersion capsule

[0026] Weigh 38.6g tortoiseshell gum, 193.3g polygala, 387.3g keel, 387.3g ganoderma lucidum, 49.3g schisandra chinensis, 193.3g Ophiopogon japonicus, 193.3g Shichangpu, 111.0g codonopsis ginseng, 66.6g ginseng, 387.3g poria cocos, the above ten flavors, except In addition to tortoise shell glue, 25% of ginseng and Poria cocos are respectively crushed into fine powder, and the remaining Poria cocos and other seven flavors such as Polygala are decocted twice, the first time is 3 hours, the second time is 2 hours, filtered, and the filtrates are combined and concentrated into Thick paste, add ginseng, poria cocos fine powder and melted tortoise shell glue, mix well, dry, powder into fine powder, sieve for later use;

[0027] Weigh PEG60001204.38g and Poloxamer1882810.22g, heat and melt, then add the fine powder of the active ingredient prepared above, stir and mix, cool and solidify rapidly, pulverize, pass through 80 mesh sie...

Embodiment 3

[0028] Embodiment 3 drug composition for benefiting the brain

[0029] Weigh 38.6g tortoiseshell gum, 193.3g polygala, 387.3g keel, 387.3g ganoderma lucidum, 49.3g schisandra chinensis, 193.3g Ophiopogon japonicus, 193.3g Shichangpu, 111.0g codonopsis ginseng, 66.6g ginseng, 387.3g poria cocos, the above ten flavors, except In addition to tortoise shell glue, 25% of ginseng and Poria cocos are respectively crushed into fine powder, and the remaining Poria cocos and other seven flavors such as Polygala are decocted twice, the first time is 3 hours, the second time is 2 hours, filtered, and the filtrates are combined and concentrated into For the thick paste, add ginseng, poria cocos fine powder and melted tortoise shell glue, mix thoroughly, dry, powder into fine powder, and sieve to get ready.

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Abstract

The invention relates to a brain-tonifying capsule pharmaceutical composition. The brain-tonifying capsule pharmaceutical composition is composed of a brain-tonifying active component, and a carrier material at a weight ratio of 1:1-2. The invention also provides a preparation method of the brain-tonifying capsule pharmaceutical composition. The brain-tonifying capsule pharmaceutical composition is capable of realizing high drug loading capacity, and increasing bioavailability.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a medicinal composition of Yinao capsules and a preparation method thereof. Background technique [0002] Yinao Capsule is composed of active ingredients of tortoise shell glue, polygala, keel, ganoderma lucidum, schisandra, Ophiopogon japonicus, Shichangpu, Codonopsis ginseng, ginseng and Poria cocos. Memory loss and the like belong to patients with insufficient heart, liver and kidney, and deficiency of both Qi and Yin. [0003] Currently commercially available Yinao Capsules mainly have the following two problems: [0004] 1. Drugs and preparations are highly hygroscopic: [0005] Because the main components of Ganoderma lucidum, Schisandra chinensis, Ophiopogon japonicus, Codonopsis pilosula, and Poria cocos all contain a large amount of polysaccharides, which have strong hygroscopicity and high viscosity during drug preparation, making it difficult ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/48A61P25/28A61K35/02A61K35/56A61K35/586
Inventor 陈斌孟莹王伟赵剑龚义华潘卫国
Owner WUHU LUYE PHARMA
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