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A kind of chondroitin sulfate sodium capsule and preparation method thereof

A chondroitin sulfate sodium and capsule technology is applied in the field of medicine to achieve the effects of improving bioavailability, good difference in loading and good quality stability

Active Publication Date: 2020-09-29
CHENGDU TONGDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patent only discloses the preparation process of sodium chondroitin sulfate and does not involve the preparation of sodium chondroitin sulfate capsules

Method used

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  • A kind of chondroitin sulfate sodium capsule and preparation method thereof
  • A kind of chondroitin sulfate sodium capsule and preparation method thereof
  • A kind of chondroitin sulfate sodium capsule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] A kind of sodium chondroitin sulfate capsule, raw material comprises sodium chondroitin sulfate, cornstarch, low-substituted hydroxypropyl cellulose, silicon dioxide and talcum powder, its formula ratio of parts by weight is: 50 parts of sodium chondroitin sulfate, 40 parts of cornstarch , 3 parts of low-substituted hydroxypropyl cellulose, 4 parts of silicon dioxide and 3 parts of talcum powder.

Embodiment 2

[0023] A kind of sodium chondroitin sulfate capsule, raw material comprises sodium chondroitin sulfate, cornstarch, low-substituted hydroxypropyl cellulose, silicon dioxide and talcum powder, its formula ratio of parts by weight is: 60 parts of sodium chondroitin sulfate, 30 parts of cornstarch , 8 parts of low-substituted hydroxypropyl cellulose, 1 part of silicon dioxide and 1 part of talc powder.

[0024] The particle size of the sodium chondroitin sulfate raw material is 80 mesh.

Embodiment 3

[0026] A kind of sodium chondroitin sulfate capsule, raw material comprises sodium chondroitin sulfate, cornstarch, low-substituted hydroxypropyl cellulose, silicon dioxide and talcum powder, its formula ratio of parts by weight is: 52 parts of sodium chondroitin sulfate, 32 parts of cornstarch , 6 parts of low-substituted hydroxypropyl cellulose, 5 parts of silicon dioxide and 5 parts of talcum powder.

[0027] The particle size of the sodium chondroitin sulfate raw material is 50 mesh.

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Abstract

The invention discloses a sodium chondroitin sulfate capsule and a preparation method thereof. The sodium chondroitin sulfate capsule comprises following raw materials in parts by weight: 50 to 60 parts of sodium chondroitin sulfate, 30 to 40 parts of corn starch, 3 to 8 parts of low-substituted hydroxypropyl cellulose, 1 to 5 parts of silica, and 1 to 5 parts of talcum powder. The preparation method comprises following steps: (1) drying; (2) mixing; (3) filling; and (4) performing bubble cap and filling capsules in a moisture barrier bag. The problem of moisture absorption of a sodium chondroitin sulfate capsule is solved, the product quality stability is improved, and the product quality can be ensured within the shelf life.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a chondroitin sulfate sodium capsule and a preparation method thereof. Background technique [0002] Chondroitin Sulfate Sodium is a sulfated chain mucopolysaccharide sodium salt extracted from pig laryngeal bone, nasal middle bone, trachea and other cartilage tissues. It is a drug for reducing blood fat and treating bone and joint diseases. Due to the super hygroscopicity of the raw material of chondroitin sulfate sodium, it is made into wet granules during granulation. During storage, due to moisture absorption, the powder will become soft and the capsule will be deformed, resulting in unqualified quality inspection. Therefore, the sodium chondroitin sulfate on the market is generally in the form of tablets. [0003] Publication No. CN105399864A, an invention patent titled "Preparation Process of High-Purity Low Molecular Weight Chondroitin Sulfate Sodium", discloses a prepar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K31/737
CPCA61K9/4866A61K31/737
Inventor 梁星
Owner CHENGDU TONGDE PHARMA
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