Composition for preparing hollow capsule and starch-base hollow capsule thereof

A technology for hollow capsules and starch matrix, which is applied to the composition for preparing hollow capsules and the field of starch matrix hollow capsules, can solve the problems of difficulty in water removal, large amount of glue liquid and no products, etc., and achieves increased hydrophilicity. performance, lowering the gelatinization temperature, and the effect of inhibiting regeneration

Active Publication Date: 2014-07-23
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, in the production process of preparing hollow capsules with it as the main raw material, the glue water material is relatively large, and it is difficult to remove water, and the glue paste is long and difficult to form. Large, the disintegration time of hollow capsules prepared with it as the main raw material is relatively long, therefore, the current domestic market share is not high
The price of starch is very low, and it is very attractive to prepare hollow capsules with it. Many domestic manufacturers have also applied for patents for starch hollow caps

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1

[0020] 55wt% hydroxypropyl cornstarch (degree of substitution DS=0.007, gelatinization temperature 70°C; hydroxypropyl cornstarch is prepared from cornstarch and propylene oxide by the conventional reaction method of starch industry), 49.5wt% methyl alcohol The base cellulose was mixed with 0.5 wt % of konjac gum to prepare a composition for preparing hollow capsules.

[0021] The above-prepared composition for preparing hollow capsules and a small amount of KCl as a coagulant (about 0.05% by weight of the composition) are mixed with water 8 times the weight of the composition and heated to gelatinize After gelatinization, starch matrix hollow capsules with good flexibility and good disintegration performance are prepared by the conventional capsule preparation process.

[0022] The prepared starch matrix hollow capsule refers to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, and adopts Tianda Tianfa ZB-1E intelligent disinte...

Example Embodiment

[0023] Example 2

[0024] 95wt% of hydroxypropyl tapioca starch (degree of substitution DS=0.93, gelatinization temperature 30° C., hydroxypropyl tapioca starch is prepared from tapioca starch and propylene oxide by the conventional reaction mode of starch industry), 4.5wt% of Chitosan and 0.5 wt% carrageenan were mixed to prepare a composition for preparing hollow capsules.

[0025] The above-prepared composition for preparing hollow capsules and a small amount of potassium citrate (about 0.15% by weight of the composition) as a coagulant aid are mixed with water that is 6 times the weight of the composition and heated After gelatinization and gelatinization, starch matrix hollow capsules with good flexibility and good disintegration performance are prepared by the conventional capsule preparation process.

[0026] The prepared starch matrix hollow capsules refer to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, and adopt Tianda Tianfa ZB-1E i...

Example Embodiment

[0027] Example 3

[0028] 79.5wt% hydroxypropyl potato starch (degree of substitution DS=0.21, gelatinization temperature 50°C, hydroxypropyl potato starch is prepared from potato starch and propylene oxide by the conventional reaction method of starch industry), 0.5wt% hydroxypropyl cellulose, 20 wt % of guar gum was mixed to prepare a composition for preparing hollow capsules.

[0029] The above-prepared composition for preparing hollow capsules and a small amount of calcium chloride (about 0.2% by weight of the composition) as a coagulant aid are mixed with water 5 times the weight of the composition and heated After gelatinization and gelatinization, starch matrix hollow capsules with good flexibility and good disintegration performance are prepared by the conventional capsule preparation process.

[0030]The prepared starch matrix hollow capsules refer to the method stipulated in the second part of the Chinese Pharmacopoeia in 2010, and adopt Tianda Tianfa ZB-1E intellig...

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PUM

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Abstract

The invention relates to a composition for preparing a hollow capsule and a starch-base hollow capsule prepared from the composition, belonging to the field of food, medicines and the like. The composition for preparing the hollow capsule is prepared by mixing hydroxypropyl starch or acid-treated hydroxypropyl starch with a reinforcing and toughening agent and a gelatinizer. The substitution degree DS of the hydroxypropyl starch or acid-treated hydroxypropyl starch is 0.007-0.93, and the gelatinization temperature is 30-70 DEG C. The composition can be heated in water to be gelatinated and colloidized to obtain the starch-base hollow capsule. The hydroxypropyl functional group is introduced to the starch molecules to modify the starch, thereby overcoming the intermolecular hydrogen bonding force of the starch, performing the toughening and reinforcing functions, effectively inhibiting starch from anabiosis, increasing the hydrophilicity of the starch molecules and lowering the gelatinization temperature; and thus, the starch-base hollow capsule has favorable disintegrability.

Description

technical field [0001] The invention relates to a composition for preparing hollow capsules used in the fields of food, medicine and the like, and starch matrix hollow capsules prepared from the composition. Background technique [0002] The use of animal-derived gelatin to make hollow capsules has a history of at least nearly 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelat...

Claims

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Application Information

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IPC IPC(8): C08L3/08C08L1/28C08L5/00C08L5/08C08L1/26
Inventor 闫丰文袁国卿
Owner INST OF CHEM CHINESE ACAD OF SCI
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