Pharmaceutical composition for treating insomnia and application thereof

A composition and technology for insomnia, applied in the field of medicine, can solve problems such as toxic side effects and adverse reactions, achieve strong sedative and hypnotic biological activity, reduce the time and frequency of awakening, and shorten the time to fall asleep

Active Publication Date: 2014-07-30
南京安泰睿医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to overcome the problem of large toxic and side effects and adverse reactions of existing drugs,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Experimental Research on the Influence of Prosteatin from Violet Flower on the Number of Autonomous Activities in Mice

[0022] Kunming mice, SPF grade, half male and half male, body weight 18-22g. 30 mice were taken, and after being adaptively fed for 3 days, they were randomly divided into blank control group, positive control group (Valantia tablet 5 mg / kg / d), and proglutinin group (20 mg / kg / d). The mice were administered intragastrically once a day for 5 consecutive days, and the blank control group was given an equal volume of normal saline. One hour after the last administration, the mice were placed in the mouse autonomic activity recorder for 5 minutes, and then the number of activities and standing times of the mice within 5 minutes were measured.

[0023] According to the test result of table 1, it can be seen that the positive control group and the prostegoglutinin group can significantly reduce the number of activities and the number of standing o...

Embodiment 2

[0028] Example 2 Experimental study on the effect of prostegoglutinin on the sleep time of mice induced by threshold dose of pentobarbital sodium

[0029] Kunming mice, SPF grade, half male and half male, body weight 18-22g. Mice sedation and hypnosis experiment 30 mice were taken, and after adaptive feeding for 3 days, they were randomly divided into blank control group, positive control group (Valantia tablet 5 mg / kg / d), and prostegoglutinin group (20 mg / kg / d). Mice were administered intragastrically once a day for 6 consecutive days, and the blank group was given an equal volume of normal saline. One hour after the last administration, each mouse was intraperitoneally injected with pentobarbital sodium 40 mg / kg. The disappearance of the righting reflex of the mice after the injection was used as the indicator of human sleep in each group, and the recovery of the righting reflex of the mice was used as the indicator of awakening. The mice in each group were recorded sleep l...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating insomnia and an application thereof. The composition is prepared from active ingredients and auxiliary materials, wherein the active ingredients comprise angelica decursiva aglycone. The pharmaceutical composition disclosed by the invention has stronger biological activity for calming down and hypnosis, has obvious effects in shortening time to fall asleep, reducing awakening time and times, and increasing asleep time, and is free of obvious side effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating insomnia and its application. Background technique [0002] Insomnia is a subjective experience that affects daytime social function due to difficulties in falling asleep and maintaining insomnia. The quality or quantity of sleep does not meet the normal physiological needs. It is the most common sleep disorder disease. Insomnia is a very common phenomenon in today's fast-paced society and intensified competition. The prevalence of insomnia is very high. The prevalence in Europe and the United States is about 20%-30%, and in my country it is 10%-20%. Insomnia can cause inattention, memory loss, judgment and daily work ability decline, and severe cases are combined with symptoms such as anxiety, obsession and depression. In addition, insomnia was an independent risk factor for coronary heart disease and symptomatic diabetes. ...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P25/20
Inventor 于法周
Owner 南京安泰睿医疗科技有限公司
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