Synthesis method of imidazo[1,2-alpha]pyridyl-3-formic acid
A synthesis method, 2-a technology, applied in organic chemistry and other directions, can solve the problems of many by-products, complicated operation, difficult to purify and purify, etc., and achieve the effects of stable product quality, mild reaction conditions and simple post-processing.
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Embodiment 1
[0027] 80mL (71.7g) of N,N-dimethylformamide dimethyl acetal is both solvent and reaction raw material, react with 2-aminopyridine (18.8g, 200mmol) at 40°C for 5 hours, and the reaction is completed to obtain N, N-dimethyl-N'-2-pyridylformamidine intermediate, rotary evaporation to remove excess N,N-dimethylformamide dimethyl acetal, add 120 mL (114g) N,N-dimethyl Formamide (DMF), NaHCO 3 (25.2g, 300mmol) and ethyl bromoacetate (50.1g, 300mmol), react at 50°C for 10 hours, after the reaction is completed, cool to room temperature, add 600 mL of water and 200 mL of ethyl acetate for extraction, separate the organic phase and the aqueous phase Extract with ethyl acetate (3×200 mL), combine the organic phases, wash with water (2×150 mL), wash with 200 mL saturated brine, anhydrous Na 2 SO 4 Dry, filter, and concentrate the filtrate to obtain the crude product of ethyl imidazo[1,2-a]pyridine-3-carboxylate, which is recrystallized from a mixed solution of n-hexane:ethyl acetate=1...
Embodiment 2
[0030] 80mL (71.7g) of N,N-dimethylformamide dimethyl acetal is both solvent and reaction raw material, react with 2-aminopyridine (18.8g, 200mmol) at 40°C for 5 hours, and the reaction is completed to obtain N, N-dimethyl-N'-2-pyridylformamidine intermediate, rotary evaporation to remove excess N,N-dimethylformamide dimethyl acetal, add 120 mL (125 g) of dioxane, K 2 CO 3 (20.8g, 150mmol) and ethyl bromoacetate (50.1g, 300mmol), react at 80°C for 10 hours, after the reaction is completed, cool to room temperature, add 600 mL of water and 200 mL of ethyl acetate for extraction, separate the organic phase and the aqueous phase Extract with ethyl acetate (3×200 mL), combine the organic phases, wash with water (2×150 mL), wash with 200 mL saturated brine, anhydrous Na 2 SO 4 Dry, filter, and concentrate the filtrate to obtain the crude product of ethyl imidazo[1,2-a]pyridine 3-carboxylate, which is recrystallized from a mixed solution of n-hexane:ethyl acetate=1:1 (volume ratio...
Embodiment 3
[0033] N,N-Dimethylformamide dimethyl acetal (80mL) is both a solvent and a reaction raw material, reacted with 2-aminopyridine (18.8g, 200mmol) at 60°C for 5 hours, and the reaction was completed to obtain N,N- Dimethyl-N'-2-pyridylformamidine intermediate, remove excess N,N-dimethylformamide dimethyl acetal by rotary evaporation, add 120 mL (103g) toluene, triethylamine (30.3g , 300mmol) and ethyl bromoacetate (50.1g, 300mmol), reacted at 100°C for 8 hours, after the reaction was completed, cooled to room temperature, added 600 mL of water and 200 mL of ethyl acetate for extraction, separated the organic phase, and used acetic acid for the aqueous phase Extract with ethyl ester (3×200 mL), combine the organic phases, wash with water (2×150 mL), wash with 200 mL saturated brine, anhydrous Na 2 SO 4 Dry, filter, and concentrate the filtrate to obtain the crude product of ethyl imidazo[1,2-a]pyridine-3-carboxylate, which is recrystallized from a mixed solution of n-hexane:ethy...
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