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Mesothelin antibody nano test paper and carbon nano tube combined cancer detection method

A carbon nanotube, single-walled carbon nanotube technology, applied in nanotechnology, nanotechnology, nanotechnology for sensing, etc., can solve the problem of high cost

Inactive Publication Date: 2014-08-06
BAI YIN
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AI Technical Summary

Problems solved by technology

Now the common diagnostic technique for pancreatic cancer in clinical practice is ELISA, which is very expensive and takes about 20 hours for each test.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] 1. Preparation of mesothelin antibody, 0.5%-2% mesothelin antibody, prepare 100g carbon nanotube dispersion, 0.5g-2g mesothelin antibody.

[0007] 2. Production of carbon nanotube dispersion: the proportion of carbon nanotubes in the water medium is 2%-10%, depending on the type of virus detected, the carbon nanotubes that can be selected are single-walled carbon nanotubes or multi-walled carbon nanotubes , or a mixture of two carbon tubes. In this experiment, 100 g of an aqueous dispersion of single-walled carbon nanotubes was prepared, and the content of carbon nanotubes was 5%.

[0008] Concrete method: use an ultrasonic pulverizer to disperse carbon nanotubes.

[0009] 3. Make the antibody-carbon nanotube mixture and let it stand for preparation. Choose bioactive test paper, soak it in the mixed solution at a temperature of 50-60 degrees for 5 hours. Dry the spare test paper and make it.

[0010] 4. During the test, extract the tester's pleural effusion or blood...

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Abstract

The invention provides a mesothelin antibodynano test paper and carbon nano tube combined cancer detection method, and solves the problems existing when a carbon nano tube is adopted to replace the traditional early cancer detection method. The combined cancer detection method is characterized in that combination of a mesothelin antibody and a carbon nano tube material is adopted, a mixed liquid composite material of a virus antibody and the carbon nano tube is used as a new virus detection tool, after the mesothelin antibody on the surface of the carbon nano tube acts with mesothelin in the blood of a tested person, the mesothelin is attached to the carbon nano tube and combined with the mesothelin antibody to expand the antibody, and the interaction between the antibody and antigen results in change of electrical conductivity of the carbon nano tube, so that the content of the mesothelin in the tested person is determined. The mesothelin antibody nano test paper and carbon nano tube combined cancer detection method has the advantages that the detection sensitivity and selectivity are good, false positive and false negative are absent, samples of a general patient and a patient suffered from pancreatitis can be ignored, and the efficiency is about 100 times of the efficiency of the conventional diagnostic test, and the method is suitable for early detection of cancers such as cholangiocarcinoma, stomach cancer, pancreatic cancer, ovarian serous carcinoma and the like.

Description

technical field [0001] The invention is specifically a mesothelin nano-test paper antibody carbon nanotube combined cancer detection method, which belongs to the technical field of early detection of malignant tumors and relates to nanomaterials, carbon nanotubes (CNTs), mesothelin antigen and characteristics of mesothelin antibody research and diagnosis. Background technique [0002] The present invention utilizes the specificity and electroluminescence effect of carbon nanotubes in terms of electrical conduction: molecules between gaps in carbon nanotubes can emit light when current passes through. Mesothelin (MSLN) is a cell surface glycoprotein and a tumor antigen. It exists in large quantities in malignant tumors such as pancreatic cancer, mesothelioma, and ovarian cancer, and the content of serum mesothelin in patients is significantly higher than that in healthy people. Measuring the content of "mesothelin" in serum can be used as an early detection method for tumor...

Claims

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Application Information

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IPC IPC(8): G01N33/68B82Y15/00
CPCG01N33/574B82Y15/00G01N33/6863
Inventor 白银
Owner BAI YIN
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