Method for designing particle implantation treatment plan

Abstract

The invention relates to a method for designing a particle implantation treatment plan. According to the requirements of treatment plan for dose distribution, an effective particle arbitration criterion is provided, particles, a target region and prior knowledge of relative position relations of OARs are reasonably utilized, and the treatment plan can be rapidly obtained. The method comprises the steps of first obtaining the particles at all possible positions, determining evaluation values of the particles according to the arbitration criterion, and enabling the particles with the minimum evaluation values to be the current optimal particles; continuously implanting the current optimal particles in the target region until the target region prescribed dose coverage reaches a predetermined value, and obtaining an initial treatment plan; when the number of puncture needles can be reduced, removing corresponding particles, selecting the current optimal particles again for implantation, and obtaining a new treatment plan; and obtaining a final treatment plan until the number of the puncture needles cannot be reduced. The method for designing the particle implantation treatment plan is combined with the characteristics of an enlightening optimization method, the number of the puncture needles can be effectively reduced on the premise that the dose distribution is guaranteed, and feasibility of the particle implantation treatment plan is improved.

Description

technical field [0001] The invention relates to computer technology, in particular to a method for designing a treatment plan for particle implantation. Background technique [0002] Radioactive seed implantation therapy, also known as brachytherapy, is a form of radiation therapy used to treat tumors. Particle implantation uses template-guided, percutaneous puncture and other interventional methods to inject radioactive particles ( 125 I, 103 Pd) implanted in the area of ​​cancerous tumors can effectively reduce the radiation dose of organs at risk (OARs) while continuously irradiating the tumor with low doses. It has good radiobiological effects and achieved good clinical results. In addition, particle implantation therapy also has the characteristics of few side effects, safe use, low cost, minimally invasive, etc., and is widely used in the treatment of tumors in the head and neck, lung, liver, pancreas, and prostate. [0003] The key to the success of radioactive see...

AI Technical Summary

Problems solved by technology

Compared with the stochastic optimization method and the deterministic optimization method, the heuristic optimization method can quickly obtain the treatment plan. However, there are still some problems in the mechanism proposed by this method to avoid particle aggregation and reduce puncture needles. It is possible to obtain a treatment plan with fewer puncture needles but a poor dose distribution. At the same time, the number of iterations is large and the calculation time is long, which cannot meet the clinical needs of intraoperative planning design

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