Preparation method for degradable porous polyethylene glycol

A technology of polyethylene glycol and porous materials is applied in the field of preparation of degradable polyethylene glycol materials and block polymer materials to achieve the effects of reducing toxic side effects, high drug loading and good biocompatibility

Inactive Publication Date: 2014-08-13
CHENGDU LVKE HUATONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

Method used

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  • Preparation method for degradable porous polyethylene glycol
  • Preparation method for degradable porous polyethylene glycol
  • Preparation method for degradable porous polyethylene glycol

Examples

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Embodiment 1

[0027] ①Preparation of star block copolymer

[0028] Using ethylene oxide as a raw material, three-arm or multi-arm star polyethylene glycol was synthesized by the classic subtractive ring-opening method. Due to the presence of hydroxyl groups at the end of the polymer, glycine protected by amino Boc-groups can be used. Under the catalysis of DCC / HOBt, it reacts with SPEG to generate SPEG derivatives. In trifluoroacetic acid / dichloromethane solution, the amino group of the above product is de-Boc-protected, and the star-shaped macromolecular initiator SPEG-NH with terminal amino functional group is obtained. 2 . The macroinitiator and benzyl glutamate carboxylic acid anhydride (NCA) are subjected to ring-opening polymerization at a certain ratio to obtain a star-shaped block polymer with PEG as the core polybenzyl glutamate as the arm. Finally, the benzyl protecting group is hydrolyzed by using a mixed solution of HBr, AcOH and trifluoroacetic acid to finally obtain a star-sh...

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Abstract

The invention discloses a preparation method for degradable porous polyethylene glycol. The preparation method comprises the following steps: with oxirane as a raw material, synthesizing three-arm polyethylene glycol by using an alkaline ring opening process; preparing a macro-molecular initiator; carrying out ring-opening polymerization with gamma-benzyl-L-glutamate-carboxylic acid anhydride (NCA) so as to obtain a star-block copolymer with PEG as a core and poly(gamma-benzyl-L-glutamate) as an arm; removing a benzyl protective group in poly(gamma-benzyl-L-glutamate) through hydrolysis so as to obtain a star polyethylene glycol / polyglutamic acid block copolymer; and adding low-molecular-weight polyglutamic acid and dissolving the block copolymer with water by using amphipathicity of the block copolymer so as to form a nanometer porous material. The block copolymer has a hexagonal prism-like structure, the continuous phase of the block copolymer is polyethylene glycol, and the material has nanometer holes. The material has nanometer holes, overcomes the disadvantage of poor processability of a traditional linear polyethylene glycol material, exerts no toxic and side effects and can be used as a drug carrier material, a medical implant material and a material for a part of an in-vivo continuous dosing apparatus.

Description

technical field [0001] The invention relates to a degradable polyethylene glycol material, in particular to a preparation method of a block polymer material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, and the final metabolite is CO 2 and H 2 O, harmless...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C08G69/40C08G65/333C08J9/26A61K47/34
Inventor 不公告发明人
Owner CHENGDU LVKE HUATONG TECH
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