Preparation method for degradable porous polyethylene glycol
A technology of polyethylene glycol and porous materials is applied in the field of preparation of degradable polyethylene glycol materials and block polymer materials to achieve the effects of reducing toxic side effects, high drug loading and good biocompatibility
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[0027] ①Preparation of star block copolymer
[0028] Using ethylene oxide as a raw material, three-arm or multi-arm star polyethylene glycol was synthesized by the classic subtractive ring-opening method. Due to the presence of hydroxyl groups at the end of the polymer, glycine protected by amino Boc-groups can be used. Under the catalysis of DCC / HOBt, it reacts with SPEG to generate SPEG derivatives. In trifluoroacetic acid / dichloromethane solution, the amino group of the above product is de-Boc-protected, and the star-shaped macromolecular initiator SPEG-NH with terminal amino functional group is obtained. 2 . The macroinitiator and benzyl glutamate carboxylic acid anhydride (NCA) are subjected to ring-opening polymerization at a certain ratio to obtain a star-shaped block polymer with PEG as the core polybenzyl glutamate as the arm. Finally, the benzyl protecting group is hydrolyzed by using a mixed solution of HBr, AcOH and trifluoroacetic acid to finally obtain a star-sh...
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