Application of SSX2IP in predicating or diagnosing tumor metastasis

A technology for tumor metastasis and application, applied in the field of oncology, can solve problems such as delaying the good timing of tumor metastasis

Inactive Publication Date: 2014-08-27
霍克克 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of specific liver cancer metastasis markers, the time window for treatment

Method used

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  • Application of SSX2IP in predicating or diagnosing tumor metastasis
  • Application of SSX2IP in predicating or diagnosing tumor metastasis
  • Application of SSX2IP in predicating or diagnosing tumor metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] Preparation of kits for predicting or diagnosing tumor metastasis / predicting patient survival

[0176] Prepare a test kit for histological detection prediction or diagnosis of whether the tumor transfers / predicts the patient's survival period, and the test kit includes:

[0177] (a) container, and the following antibody specific for SSX2IP that is positioned in the container: the antibody (purchased from Abcam and Sigma company) of people's anti-SSX2IP; With

[0178] (b) and a label or an instruction, the label or instruction indicates that the kit is used to predict whether the tumor is metastasized or the survival period of the patient.

Embodiment 2

[0179] Example 2 Correlation between SSX2IP protein expression and tumor thrombus formation and tumor envelope integrity

[0180] Materials: 53 samples of liver cancer patients were collected from Zhongshan Hospital Affiliated to Fudan University. The informed consent of the subjects and the approval of the hospital's ethics review board were obtained.

[0181] Methods: The kit prepared in Example 1 was used, and the grouping conditions were shown in Table 1; observation indicators: tumor size, tumor thrombus formation, and tumor capsule integrity; the expression level of SSX2IP in the tumor tumor was measured, and the effect of its expression level on Significance of complications in cancer patients.

[0182] Result: as shown in Table 1:

[0183] Table 1

[0184]

[0185] In malignant tumors, the size of the tumor represents the degree of malignancy to a certain extent; while the formation of tumor embolus indicates that the tumor has the ability to start migration and ...

Embodiment 3

[0189] Example 3 Correlation between SSX2IP protein expression and survival time of cancer patients

[0190] Materials: 51 patients with liver cancer were followed up after operation, and the informed consent of the subjects and the approval of the ethics review committee of the hospital were obtained.

[0191] Method: According to the patient's information, postoperative telephone follow-up, which lasted for more than five years

[0192] The result is as figure 1 Shown:

[0193] Cancer patients with relatively high expression of SSX2IP had a shorter survival time than those with low expression of SSX2IP. Among them, the high expression level therefore, the expression level of SSX2IP can be used to predict the survival time of cancer patients.

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Abstract

The invention discloses an application of SSX2IP in predicating or diagnosing tumor metastasis. Specifically, the invention provides an application of SSX2IP gene or protein in preparing a reagent or a kit for detecting the tumor metastasis. Studies demonstrate that SSX2IP gene and an expression product thereof can be used as a specific marker gene for diagnosing or predicating tumor (for example, liver cancer) metastasis, and is beneficial to diagnose and predicate the tumor metastasis more accurately and early.

Description

technical field [0001] The present invention relates to the field of oncology. More specifically, the present invention relates to the application of SSX2IP gene or protein in the diagnosis or prediction of tumor metastasis. The invention also relates to the application of the SSX2IP inhibitor in the prevention and treatment of tumor metastasis, tumor cell migration and chemotherapy drug resistance. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, ranking fifth in the world (malignant tumors) in incidence and third in cancer-related death. In China, its incidence rate is second only to lung cancer, ranking second bit. [0003] The liver has rich blood supply, high metastasis rate, and poor prognosis of patients with metastasis. The existing biomolecules that can be used as markers of primary liver cancer are generally considered to have the following four categories: carcinoembryonic and glycoprotein antigens; enzyme...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/68
CPCC12Q1/6886C12Q2600/158G01N33/6893G01N2800/7028
Inventor 霍克克李璞
Owner 霍克克
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