Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Fabrication method of microneedles based on inclined casting mold

A manufacturing method and microneedle technology, which is applied in the fields of medical cosmetic devices and microneedles for medical injection, can solve problems such as increasing process difficulty, reducing yield, and difficult installation, and achieves the effect of low process complexity and easy control of inclination angle

Active Publication Date: 2016-08-03
厦门薇针医药科技有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can improve the sharpness of the needle to a certain extent, the bottom of the substrate will also become inclined, making it difficult to install
In addition, oblique exposure significantly increases the difficulty of the process, increases the cost and reduces the yield

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fabrication method of microneedles based on inclined casting mold
  • Fabrication method of microneedles based on inclined casting mold
  • Fabrication method of microneedles based on inclined casting mold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1, such as image 3 Shown:

[0050] A method for manufacturing microneedles based on an inclined mold, comprising the following steps:

[0051] A) Use MEMS planar technology or laser ablation technology to make the same plane microneedle female mold 1, the material can be PDMS, the angle α between the needle tip is 90°, the thickness of the needle body is h, and the length of the needle body and the base is l;

[0052] Utilizing the MEMS plane process to make the same plane microneedle female mold 1 includes the following steps:

[0053] 1) Use AUTOCAD to draw a two-dimensional microneedle pattern and make a mask. The coplanar microneedle includes one or more needle bodies and a base connecting the needle bodies, and the needle body and the base are in the same plane. The length of the needle body is 300 μm, the width is 200 μm, the gap between the needle bodies is 500 μm, a single row contains 10 needle bodies, and the height of the base is 1 mm.

[0054] 2...

Embodiment 2

[0068] Example 2, such as Figure 4 Shown:

[0069] Another microneedle manufacturing method based on an inclined mold belonging to the same inventive idea has the following steps:

[0070] A) making the same plane microneedle female mold 1;

[0071] B) The coplanar microneedle female mold 1 is inclined by sticking the coplanar microneedle female mold 1 on the inclined surface of the inclined platform 2, and the axis of the needle body of the microneedle groove is perpendicular to the intersection of the inclined surface of the inclined platform 2 and the horizontal plane line, the tip of the microneedle groove of the same plane microneedle female mold 1 is at a low point, and the base of the microneedle groove is at a high point, that is, the needle body of the microneedle groove is facing downward;

[0072] C) pouring a liquid mold filling material into the microneedle groove of the coplanar microneedle female mold 1, and the coplanar microneedle female mold 4 with an inve...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a microneedle manufacturing method based on an inclined casting mold, which has the following steps: making a microneedle female mold on the same plane; tilting the same plane microneedle female mold so that the needle tip of the microneedle groove is at a high point; pouring liquid microneedle material ; Take out the microneedles from the female mold after curing. Another microneedle manufacturing method based on an inclined casting mold belonging to the same inventive idea has the following steps: making the same plane microneedle female mold; tilting the same plane microneedle female mold so that the needle tip of the microneedle groove is at a low point; pouring liquid The mold filling material is cured to obtain a female mold with inverted wedge-shaped microneedle grooves; the obtained female mold is used to make microneedles through a casting method and a hot embossing method. The beneficial effects of the present invention are: smaller included angles of microneedles can be obtained, generally up to 10°, and needle tips are sharper; compared with the traditional micro-mold casting method, the inclined casting method only changes the inclination angle of the mold placement, and only needs to The inclined platform is added, and the inclination angle is easy to control, and the process complexity is low.

Description

technical field [0001] The invention relates to the technical field of medical cosmetic devices and microneedles for medical injection, in particular to a microneedle manufacturing method based on an inclined casting mold. Background technique [0002] Microneedle transdermal drug delivery is an emerging drug delivery technology. By pressing the microneedles, a large number of micron-sized pores are generated in the stratum corneum and epidermis of the skin, and the drug penetrates into a large number of blood vessels in the dermis of the skin through these pores, thereby achieving Transdermal administration. Microneedles can achieve integrated, portable, painless, precise, and efficient drug delivery during the treatment process, and have unparalleled advantages in diabetes treatment, chemotherapy, and vaccination. In addition, due to the sharp tip and small size of the microneedle, there will be no pain or bleeding when administering the drug, and the minimally invasive s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B29C39/02B29C39/26
Inventor 游学秋王志峰商院芳
Owner 厦门薇针医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com