Fungal polysaccharide and composition thereof with anti-gastric ulcer effects

A technology of fungal polysaccharides and compositions, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2014-11-19
高其品
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report on the preparation method of several fungal polysaccharides such as Pleurotus eryngii, white jade mushroom, Tricholoma eryngii,

Method used

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  • Fungal polysaccharide and composition thereof with anti-gastric ulcer effects
  • Fungal polysaccharide and composition thereof with anti-gastric ulcer effects
  • Fungal polysaccharide and composition thereof with anti-gastric ulcer effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Take 10 kg of fresh Pleurotus eryngii fruiting bodies, remove impurities, cut into sections, add 4 times the amount of normal water to decoct for 3 hours, collect the decoction liquid, add 3 times the amount of water to decoct the residue for 3 hours, discard the residue, and decoct together solution, concentrated to a relative density of 1.2 (measured at 60°C). Under stirring, slowly add 3 times the amount of 95% ethanol, and let stand overnight. The precipitate was collected and dried under reduced pressure to obtain crude polysaccharide. The crude polysaccharide is dissolved in water to make a 20% aqueous solution, and each gram of crude polysaccharide in the aqueous solution passes through a mixed column (L:Ф; 1:7) composed of 2 grams of 717 cation exchange resin and 732 anion exchange resin (1:1), After elution with 3 column volumes of pure water, the eluate was collected, concentrated appropriately, and freeze-dried or spray-dried to obtain 780 grams of purified ...

Embodiment 2

[0081] Take 10 kg of fresh crab-flavored mushroom fruiting bodies, remove impurities, cut into sections, add 3 times the amount of normal water to decoct for 3 hours, collect the decoction liquid, add 4 times the amount of water to decoct the residue for 2 hours, discard the residue, and decoct together solution, concentrated to a relative density of 1.3 (measured at 60°C). Under stirring, slowly add 3 times the amount of 95% ethanol, and let stand overnight. The precipitate was collected and dried under reduced pressure to obtain crude polysaccharide. The crude polysaccharide is dissolved in water to make a 20% aqueous solution, and each gram of crude polysaccharide in the aqueous solution passes through a mixed column (L:Ф; 1:7) composed of 2 grams of 717 cation exchange resin and 732 anion exchange resin (1:1), After elution with 3 column volumes of pure water, the eluate was collected, concentrated appropriately, and freeze-dried or spray-dried to obtain 795 grams of puri...

experiment example 3

[0083] Take 400g of purified Pleurotus eryngii polysaccharides and 400g of crab-flavored mushroom polysaccharides, and mix them evenly to obtain 800 grams of fungal polysaccharide compositions.

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Abstract

The invention relates to a fungal polysaccharide and a composition thereof with anti-gastric ulcer effects. According to the invention, a crude polysaccharide is obtained from fruiting bodies of pleurotus eryngii, white beech mushroom, calocybe gambosa, pleurotus citrinopileatus and hypsizygus mammoreus bigelow and the crude polysaccharide is purified with a purification method adopting a mixed pillar consisting of 717 cation exchange resin and 732 anion exchange resin; the anti-gastric ulcer effect of the purified fungal polysaccharide and the composition thereof is obviously strengthened; meanwhile, substances which possibly stimulate an immune system to generate allergy are removed, so that the fungal polysaccharide and the composition thereof are safer to use and are also beneficial to quality control of a product. According to the invention, the fungal polysaccharide and the composition thereof are proved to have obvious effects of preventing and treating gastric ulcer by experiments for the first time.

Description

technical field [0001] The invention relates to a preparation method of fungal polysaccharide and its composition, and a new application of the fungal polysaccharide and its composition in treating and preventing gastric ulcer, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Internationally, fungal polysaccharides are called "Biological Response Modulators", or "BRMs" for short, which have a wide range of pharmacological effects, such as regulating immune function, anti-tumor, anti-oxidation, anti-ulcer, anti-bacteria, anti-virus and anti-coagulation. Improve liver function and detoxification, improve animal hypoxia tolerance and oxygen utilization, reduce blood viscosity, increase myocardial contractility, improve heart rhythm, lower blood sugar, sedative, analgesic, asthma, cough, chemical Phlegm and other effects. Although fungal polysaccharides are very effective and known as the health guards of the 21st century, the publ...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/04
Inventor 徐多多王明星高阳
Owner 高其品
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