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Calixarene functionalized gold nanoparticle and preparation method thereof

A technology of gold nanoparticles and calixarene, applied in the direction of nanotechnology, nanotechnology, nanotechnology for sensing, etc., can solve the problems of time-consuming, complicated, and application obstacles of CEC4 functionalized gold nanoparticles, and achieve a convenient method , good stability, and the effect of simple preparation method

Inactive Publication Date: 2014-11-19
SHANGHAI UNIV
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Problems solved by technology

Due to the solubility limitation of CEC4, the phase transition method for the synthesis of CEC4-functionalized gold nanoparticles by Secchi and other researchers is complex and time-consuming, which to a certain extent has greatly hindered the application of CEC4-functionalized gold nanoparticles.

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  • Calixarene functionalized gold nanoparticle and preparation method thereof

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Embodiment 1

[0015] Example 1: The preparation method and steps of calix[4]arene functionalized gold nanoparticles and biogenic amine colorimetric detection in this example are as follows:

[0016] (1) Preparation of CEC4 functionalized gold nanoparticles: First, add DMSO solution into a beaker at room temperature, keep away from light and stir rapidly; then, quickly add cysteamine solution, CEC4 solution and chloroauric acid solution at one time, After stirring for 2-3 minutes, the color of the solution changes from light yellow to colorless; then, quickly add the newly prepared sodium borohydride solution and continue stirring until the color of the solution turns brownish red; finally, add an appropriate amount of water to the brownish red solution After stirring for 30 minutes, the solution turned dark red and was stored in a brown bottle at 4°C.

[0017] (2) Colorimetric detection of biogenic amines: take 50 μL of each of the four kinds of biogenic amines (spermine, spermidine, cadav...

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Abstract

The invention relates to a calixarene functionalized gold nanoparticle and a preparation method thereof. Calixarene CEC4 is modified to the surface of a gold nanoparticle by a gold-mercapto key; the mass ratio of the calixarene CEC4 and the gold nanoparticle is (1:1)-(1:2), and the gold nanoparticle is usually not expressed by mass but generally by concentration. The concentration ratio of the calixarene CEC4 and the gold nanoparticle is 2000000:23; the particle diameter of the gold nanoparticle is 13 nm. According to the calixarene functionalized gold nanoparticle and the preparation method thereof, functionalization of the water insoluble CEC4 to the gold nanoparticle is further realized, at the same time, the CEC4 functionalized gold nanoparticle has high specificity in biogenic amine detection, and a rapider method is provided for detection of the content of biogenic amine in a biological sample through a constructed biogenic amine colorimetric sensor by the aid of the important characteristic of the CEC4 functionalized gold nanoparticle.

Description

technical field [0001] The invention relates to a calixarene functionalized gold nano particle and a preparation method thereof. Background technique [0002] Calixarenes are the third generation host supramolecular compounds. Compared with the first-generation supramolecular compound crown ether and the second-generation supramolecular compound cyclodextrin, calixarene has the advantages of rich π-electron hydrophobic cavity, adjustable size, variable conformation, easy modification, etc., and can chelate And transport cations, form inclusion complexes with neutral molecules, etc., can carry out various selective functionalization to introduce suitable substituents, and can form complexes with almost all metals. Calix[4]arene crown ether is an important class of calixarene derivatives. It has been reported in the literature that calix[4]arene crown ether (CEC4) has a variety of complexing functions, and has a With specific recognition ability. However, due to the water i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00G01N21/31B82Y30/00B82Y40/00B82Y15/00
Inventor 李根喜陈红霞张江江高艳敏
Owner SHANGHAI UNIV
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