Application of FGF (fibroblast growth factor) 9 in preparation of osteoarthritis cartilage repair promotion medicine

A technology for cartilage repair and osteoarthritis, applied in drug combinations, bone diseases, pharmaceutical formulations, etc., can solve the problems of articular cartilage damage and unclear effects, achieve good application prospects, relieve degradation, and slow down the process of hypertrophy Effect

Inactive Publication Date: 2014-11-26
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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However, the influence and role of FGF9 on the rep

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  • Application of FGF (fibroblast growth factor) 9 in preparation of osteoarthritis cartilage repair promotion medicine
  • Application of FGF (fibroblast growth factor) 9 in preparation of osteoarthritis cartilage repair promotion medicine
  • Application of FGF (fibroblast growth factor) 9 in preparation of osteoarthritis cartilage repair promotion medicine

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Embodiment Construction

[0013] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The experimental methods for which specific conditions are not indicated in the examples are usually in accordance with conventional conditions, or in accordance with the conditions suggested by the manufacturer.

[0014] 1. Effects of FGF9 treatment on the expression of MMP13 and Collagen X in articular chondrocytes in an inflammatory environment

[0015] Human primary articular cartilage tissue samples were taken from the still normal human knee articular cartilage resected after self-arthroplasty surgery, separated, digested, inoculated and cultured to an appropriate cell density, first treated with 10ng / ml FGF9 for 30 minutes (control). No treatment), then add 10ng / ml IL-1β for 24 hours (FGF9 still exists in the medium, the control is not treated), then use Trizol method to extract the total mRNA of primary chondrocytes, reverse transcrib...

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Abstract

The invention discloses application of FGF (fibroblast growth factor) 9 in preparation of osteoarthritis cartilage repair promotion medicines, researches find the FGF9 can play the role of retardation of abnormal differentiation of articular cartilage cells in the articular cartilage cells in the inflammatory environment, the FGF9 can alleviate the articular cartilage degradation in an osteoarthritis model in mice, can inhibit key enzyme MMP-13 of articular cartilage degradation, can slow down the hypertrophy process of articular cartilage, can be use for preparation of the osteoarthritis cartilage repair promotion medicines, and has good potential application prospect in the osteoarthritis treating field.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a new use of a cell growth factor in the field of pharmacy. Background technique [0002] Osteoarthritis is a degenerative disease, which is caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and many other factors. Osteoarthropathy. Articular cartilage damage is the main pathological change in osteoarthritis. There is no or little self-repair ability after articular cartilage injury, which is related to the lack of blood vessels, nerves and lymphatic innervation in articular cartilage. At present, the main treatment measures for the repair of articular cartilage damage include topical medication, chondrocyte transplantation, surgery (joint replacement), etc. Although the symptoms can be relieved to a certain extent, due to the failure to fully activate the repair mechanism of the articular cartilage itself, the repair is often inc...

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Application Information

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IPC IPC(8): A61K38/18A61P19/02
Inventor 陈林唐浚洲苏楠杜晓兰
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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