Pharmaceutical composition containing peptide
A technology for pharmaceutical compositions and epitope peptides, which can be used in pharmaceutical combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as increased patient burden, and achieve effective treatment and full anti-tumor effect.
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[0124] Peptides for Injection:
[0125] The peptides described in Table 1 were synthesized as peptides for injection. As shown in Table 1, the predicted pI of these peptides is in the range of 5.2 to 10.4, and the solubility characteristics are expected to be different. These peptides are peptides derived from tumor-specific antigens confirmed to have the ability to induce cytotoxic T cells.
[0126] Water for injection: The water for injection uses the manufacturing water specified in the Japanese Pharmacopoeia.
[0127] [Table 1]
[0128] Peptide name
Embodiment 1
[0132] Embodiment 1 uses the preparation of the single peptide injection that sodium carbonate solution is arranged
[0133] Sodium carbonate decahydrate (Na 2 CO 3 10H 2 (0) 41 mg was dissolved in 1 mL of water for injection to obtain water for injection containing sodium carbonate. Regarding the peptides insoluble in water for injection in Comparative Example 1, peptides-1, 2, 4, 7, and 10 were added to 1 mL of sodium carbonate-containing water for injection in order to prepare a single preparation of each peptide. The total amount of the injected peptide was dissolved by stirring at room temperature to prepare a colorless and transparent peptide solution. Thereafter, the obtained peptide solution was subjected to filter sterilization (0.22 μm filter) to obtain an injection.
[0134]The dosage of the peptide was varied within the range of 5-20 mg, and injections were prepared at each concentration stage. As for peptides-2, 4, 7, and 10, injections could be obtained at a...
Embodiment 2
[0135] Embodiment 2 uses the preparation of the single peptide injection that has arginine solution
[0136] Dissolve 40 mg of L-arginine in 1 mL of water for injection to obtain arginine-containing water for injection. Regarding the peptides insoluble in water for injection in Comparative Example 1, peptides-1, 2, 4, 7, and 10 were added to 1 mL of arginine-containing water for injection in order to prepare a single preparation of each peptide. The total amount of the injected peptide was dissolved by stirring at room temperature to prepare a colorless and transparent peptide single solution. Thereafter, the obtained peptide solution was subjected to filter sterilization (0.22 μm filter) to obtain an injection.
[0137] The input amount of the peptide was changed within the range of 5-20 mg, and injections were prepared at each concentration stage. As for peptides-2, 4, 7, and 10, injections could be obtained at any input amount tested. With regard to peptide-1, it was con...
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