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Danefukang granules and preparation method thereof

The technology of Dan'e Fukang and granules is applied in the field of Dan'e Fukang formula drug extraction and the preparation of granules, and can solve the problems of affecting the solubility quality of granules, poor water solubility, etc.

Inactive Publication Date: 2014-12-03
SICHUAN DIHON MEDICAL DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor water solubility of gum resin components, the introduction of such substances affects the solubility quality of granules

Method used

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  • Danefukang granules and preparation method thereof
  • Danefukang granules and preparation method thereof
  • Danefukang granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Recipe: 450 parts by weight of purple salvia miltiorrhiza, 250 parts by weight of curcuma, 150 parts by weight of notoginseng, 250 parts by weight of angelica, 175 parts by weight of Corydalis, 250 parts by weight of Dian Bupleurum, 250 parts by weight of red peony root, 175 parts by weight of Sanleng, Cyperus cyperi 150 parts by weight, 100 parts by weight of licorice. The above ten flavors, purple salvia miltiorrhiza, curcuma, notoginseng, angelica, and corydalis are extracted with 40% ethanol under reflux, the ethanol extract is collected, the ethanol is recovered under reduced pressure and concentrated, and concentrated to obtain extract A. Add bupleurum and other five flavors to 6 times the weight of the medicinal materials in water, decoct twice for 2 hours each time, combine the decoction, filter, and concentrate the filtrate to obtain extract B, combine the above A and B extracts, add dextrin to make granules , that is.

Embodiment 2

[0019] Weigh the medicinal materials according to the formula ratio in Example 1, take purple salvia miltiorrhiza, curcuma, notoginseng, angelica, and corydalis, extract with 50% ethanol under reflux, collect the ethanol extract, recover ethanol under reduced pressure and concentrate, and concentrate to obtain extract A , the medicinal dregs after ethanol extraction and the other five flavors such as Bupleurum yunnanensis are added to 7 times the weight of the medicinal materials in water, decocted twice, each time for 2 hours, the decoctions are combined, filtered, the filtrate is concentrated to obtain extract B, and the above A, B extract, add starch to make granules, that is to say.

Embodiment 3

[0021] Weigh the medicinal materials according to the formula ratio in Example 1, take purple salvia miltiorrhiza, curcuma, notoginseng, angelica, and corydalis, extract with 60% ethanol under reflux, collect the ethanol extract, recover ethanol under reduced pressure and concentrate, and concentrate to obtain extract A , the medicinal dregs after ethanol extraction and the remaining five flavors such as Bupleurum yunnanensis were added to 8 times the weight of the medicinal materials in water, decocted twice, each time for 2 hours, the decoction was combined, filtered, the filtrate was concentrated to obtain extract B, and the above A, B extract, add auxiliary materials (sucrose: dextrin = 3:1) to make granules, that is.

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Abstract

The invention discloses Danefukang granules and a preparation method thereof. The method includes the steps: extracting 90 parts by weight of salvia miltiorrhiza bunge, 50 parts by weight of rhizoma zedoariae, 30 parts by weight of pseudo-ginseng, 50 parts by weight of angelica sinensis and 35 parts by weight of rhizoma corydalis by ethanol, carrying out reduced pressure recovery of ethanol, and concentrating to obtain an extract A; carrying out water addition and decoction on the drug dregs after ethanol extraction, 50 parts by weight of Yunnan radix bupleuri, 50 parts by weight of radix paeoniae rubra, 35 parts by weight of rhizoma sparganii, 30 parts by weight of rhizoma cyperi and 20 parts of liquorice for two times, merging the decoction liquids, filtering, and concentrating to obtain an extract B; and merging the extract A and the extract B, adding auxiliary materials, and preparing the granules. The method comprises that based on a Danefukang decoction agent, the low-concentration ethanol is adopted to extract the medicinal materials, and then the granules are prepared by ways of concentration, granulation and the like. Compared with granules prepared by high-concentration ethanol extraction, the granules obtained by the method have the drug water solubility enhanced, so that appearance properties of the granules after dissolving are significantly improved.

Description

technical field [0001] The invention relates to the field of extraction and preparation of traditional Chinese medicines, in particular to a method for extracting Dan'e Fukang formula drugs and preparing granules thereof. Background technique [0002] Dan'e Fukang Decoction is a variety recorded in the Ministry of Health standard (WS-10227 (ZD-0227)-2002), which consists of Zidanshen, Panax notoginseng, Bamboo-leaf Bupleurum, Chishao, Angelica, Sanleng, Cyperus , Corydalis, licorice and other components. The preparation method of the original decoction is: the above ten medicinal materials, purple salvia, curcuma, notoginseng, angelica, Corydalis zhaoliu extract and the percolation method under the item of extract (Chinese Pharmacopoeia 2000 edition one appendix Io), with 70 % ethanol as a solvent, percolation after soaking for 24 hours, collecting the filtrate, recovering ethanol under reduced pressure and concentrating to a thick paste with a relative density of 1.30 (50°...

Claims

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Application Information

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IPC IPC(8): A61K36/902A61K9/16A61P15/00A61P29/00
Inventor 李存勇朱绪民侯亚会胡鹃龙绍疆
Owner SICHUAN DIHON MEDICAL DEV
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