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Hollow zirconium dioxide nano-material with tumor microwave hyperthermia and CT imaging functions, as well as preparation method and application

A zirconium dioxide and nanomaterial technology is applied in the field of multifunctional hollow zirconium dioxide nanomaterials and their preparation, and achieves the effects of good CT enhancement performance, good clinical application value, and good diagnosis and treatment effect.

Active Publication Date: 2014-12-17
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multifunctional nanomaterial of the present invention has not yet been reported

Method used

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  • Hollow zirconium dioxide nano-material with tumor microwave hyperthermia and CT imaging functions, as well as preparation method and application
  • Hollow zirconium dioxide nano-material with tumor microwave hyperthermia and CT imaging functions, as well as preparation method and application
  • Hollow zirconium dioxide nano-material with tumor microwave hyperthermia and CT imaging functions, as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Disperse 1-butyl-3-methylimidazolium tetrafluoroborate in deionized water with a volume fraction of 1%, and disperse evenly by ultrasonication or stirring;

[0040] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazolium tetrafluoroborate dispersion obtained in step 1), with a mass volume fraction of 1 mg mL -1 , sonicate for about 30 minutes under vacuum;

[0041] (3) The hollow zirconia nanomaterial loaded with 1-butyl-3-methylimidazolium tetrafluoroborate obtained in step 2) is sequentially washed with absolute ethanol and deionized water;

[0042] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0043] From Figure 1-4 It can be clearly observed that the obtained hollow zirconia nanomaterials are uniformly distributed, the particle size distribution is narrow, the diameter is 350nm, and the shell thickness is 50nm, and it can...

Embodiment 2

[0049] (1) Disperse 1-butyl-3-methylimidazolium hexafluorophosphate in deionized water with a volume fraction of 10%, and disperse evenly by ultrasonication or stirring;

[0050] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazolium hexafluorophosphate dispersion obtained in step 1), with a mass volume fraction of 10 mg mL -1 , sonicate for about 60 minutes under vacuum;

[0051] (3) washing the hollow zirconia nanomaterials loaded with 1-butyl-3-methylimidazolium hexafluorophosphate obtained in step 2) with absolute ethanol and deionized water successively;

[0052] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0053] The multifunctional hollow zirconia nanomaterial prepared in this example is used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heating experiments and tumor hyperthermia effects are ...

Embodiment 3

[0058] (1) Disperse 1-butyl-3-methylimidazole L lactate in deionized water with a volume fraction of 3%, and disperse evenly by ultrasonication or stirring;

[0059] (2) Add hollow zirconia nanomaterials to the 1-butyl-3-methylimidazole L lactate dispersion obtained in step 1), and the mass volume fraction is 2 mg mL -1 , sonicate for about 40 minutes under vacuum;

[0060] (3) The hollow zirconia nanomaterials loaded with 1-butyl-3-methylimidazole L-lactate obtained in step 2) are washed with absolute ethanol and deionized water successively;

[0061] (4) The hollow zirconia nanomaterial obtained in step 3) has both CT enhancement and microwave sensitization properties, and is a multifunctional hollow nanomaterial.

[0062] The multifunctional hollow zirconia nanomaterial prepared in this example is used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heating experiments and tumor hyperthermia effects are as follows:

[0063] Disperse the...

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Abstract

The invention discloses a multifunctional hollow zirconium dioxide nano-material with tumor microwave hyperthermia and CT imaging functions. The hollow nano-material has a diameter of 50-1000nm and a shell thickness of 10-500nm. The multifunctional hollow zirconium dioxide nano-material is narrow in particle diameter distribution, and controllable in shell thickness and size, and has excellent dispersity in water and ethanol. The hollow zirconium dioxide nano-material is simultaneously applied to the field of tumor microwave hyperthermia and CT imaging for the first time, and an excellent treating and imaging effect is obtained, so that the diagnosis and treatment efficiency can be greatly improved, the target of integrating diagnosis and treatment can be realized, and the hollow zirconium dioxide nano-material has an excellent clinical application value.

Description

technical field [0001] The invention relates to the field of hollow zirconia nanometer technology and its biological application. More specifically, it relates to a multifunctional hollow zirconia nanomaterial with functions of microwave hyperthermia for tumors and CT imaging, its preparation method and application. Background technique [0002] At present, the incidence of cancer is still on the rise worldwide, and the status of cancer is not optimistic (Nanoscale, 2012, 4, 330-342, Nanoscale, 2013, 5, 12409-12424). In 2013, the number of new cancer cases in the world was more than 14 million, and it is expected to rise to more than 20 million by 2030. For my country, one person is diagnosed with cancer every 6 minutes in the whole country, 8550 people become cancer patients every day, about 22% of people suffer from cancer, and one person dies of cancer in every 7-8 people, the cumulative rate (0 ~74 years old) is 12.94% for Chinese residents to die from cancer. Due to v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/04A61P35/00
Inventor 孟宪伟史海堂谭龙飞
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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