Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors

A compound, nitro technology, applied in the field of kinase inhibitor compounds, can solve problems such as signal loss
CN104254533AActive Publication Date: 2014-12-31BRISTOL MYERS SQUIBB CO
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BRISTOL MYERS SQUIBB CO
Publication Date
2014-12-31

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Abstract

Compounds having the following formula (I) or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C-R7, are useful as kinase modulators, including IRAK-4 modulation.
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Description

technical field

[0001] The present invention relates to compounds useful as inhibitors of kinases, including modulation of IRAK-4. Provided herein are heterocyclic substituted pyridyl compounds, compositions including these compounds, and methods of using them. The present invention also relates to pharmaceutical compositions comprising at least one compound of the present invention for use in the treatment of disorders associated with the modulation of kinases and methods of inhibiting the activity of kinases, including IRAK-4 in mammals. Background of the invention

[0002] Members of the Toll / IL-1 receptor family are important regulators of inflammation and host resistance. The Toll-like receptor (TLR) family recognizes molecular features derived from infectious organisms, including bacteria, fungi, parasites, and viruses, among others (reviewed in Kawai, T., et al. 2010, Nature Immunol. 11:373-384). Ligand binding to the receptor induces dimerization of the adapter mol...

Claims

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