Preparation method of anti-adhesive membrane used after neurosurgical operations

Abstract

The invention discloses a preparation method of an anti-adhesive membrane used after neurosurgical operations. The method comprises the following steps: dissolving polylactide, artificial protein and pure natural collagen in an organic solvent to obtain a macromolecular solution; conducting electrostatic spinning treatment to the macromolecular solution to obtain an electrostatic spinning film, wherein the voltage of electrostatic spinning is 25.2KV and a receiving distance is 21cm; and drying the electrostatic spinning film in a drying oven for 3-3.5h at 50-55 DEG C to obtain the anti-adhesive membrane. The anti-adhesive membrane prepared by the preparation method disclosed by the invention is simple to prepare, good in ductility and good in anti-adhesion capacity.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a preparation method of an anti-adhesion film for neurosurgery. Background technique [0002] Adhesion after surgery is one of the common complications of surgery. According to authoritative reports, more than 50-100% of abdominal and pelvic surgery will lead to different degrees of adhesion. The sequelae are: continuous pain at the surgical site, and even loss of part of the function ; Therefore, if preventing adhesions in neurosurgery and other operations is still one of the important research topics at home and abroad. In recent years, it has become a common practice in the world to prevent postoperative adhesions by implanting isolation materials, that is, anti-adhesion materials, in the parts prone to postoperative adhesions. At present, sodium hyaluronate is commonly used in clinical practice to prevent postoperative adhesions, but due to its purity It is not high...

AI Technical Summary

Problems solved by technology

In recent years, it has become a common practice in the world to prevent postoperative adhesions by implanting isolation materials, that is, anti-adhesion materials, in the parts prone to postoperative adhesions. At present, sodium hyaluronate is commonly used in clinical practice to prevent postoperative adhesions, but due to its purity It is not high, has no anti-inflammatory effect, and the effect after use is not satisfactory; many countries have also tried to use absorbable polylactic acid solid materials to achieve the purpose of isolating wounds and preventing and reducing adhesions, but its strength and rigidity are too strong and flexible Insufficient resistance, so the anti-adhesion effect is not ideal