37 results about "Artificial protein" patented technology

The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.

It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohorns or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, a labeling, etc., and a complex of the above-described peptide molecule, artificial protein or chimeric molecule with a nanographite structure. By panning peptide-presenting phages bonded to nanographite structures, a nanographite structure-binding peptide capable of specifically recognizing nanographite structures such as carbon nanohorns or carbon nanotubes is obtained.

Provided is an artificial protein that is present in a folded part of the secondary structure in a structural region having the antigen-binding activity of a protein having at least an antigen-bindingregion of an antibody and that is fused with a physiologically active peptide at a site exposed on the protein surface.

The invention relates to an ecological breeding method for honeysuckle flower chicken. The method comprises a heat preservation eliminating stage, a feed training stage and a stocking stage, wherein at the heat preservation eliminating stage, 5kg of insect protein additive and 1kg of Chinese medicinal epidemic prevention additive are added into 100kg of basal feed; at the feed training stage, adding 1-1.5kg of insect protein additive and 1.5kg of Chinese medicinal epidemic prevention additive into 100kg of basal feed; at the stocking stage, adding 1-1.5kg of insect protein additive and 2kg of Chinese medicinal epidemic prevention additive into 100kg of basal feed; at the stocking stage, 1-1.5kg of insect protein additive, 2kg of Chinese medicinal epidemic prevention additive and 1kg of meat quality improving additive are added into 100kg of basal feed two months before marketing in order to improve the meat quality of the honeysuckle flower chicken. According to the ecological breeding method for honeysuckle flower chicken, hormones, antibiotics and artificial proteins are not fed, and a stocking way is adopted, so that the obtained honeysuckle flower chicken have the advantages of good mouthfeel, compact meat quality and abundant nutrients.