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Traditional Chinese medicinal composition with antimicrobial and antiinflammation effects and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for treating chronic pharyngitis and its preparation, can solve the problems of strong irritation, inaccurate curative effect, and unreasonable price, and achieve definite curative effect and treatment of chronic pharyngitis Effect

Active Publication Date: 2015-01-14
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are not many Chinese patent medicines for treating chronic pharyngitis on the market. Some of the existing medicines have insufficient curative effects, some are not reasonably priced, and some are more irritating during the treatment process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Chinese medicine composition with antibacterial and anti-inflammatory effects

[0042] 1. Composition: Angelica 4.5kg, Codonopsis 4.5kg, Andrographis paniculata 4.5kg, Dianmianzhen 4.5kg, Rosa chinensis root 8kg, Millipeda 8kg, Gongluomu 8kg, Qianjinba 8kg.

[0043] 2. Extraction method:

[0044] 1) Weigh 4.5kg of Angelica sinensis according to the proportion, extract it with 0.6L (0.13 times the volume of Angelica sinensis weight) of 95% ethanol, the extraction temperature is 45°C, the extraction pressure is 30Mpa, the analytical pressure is 10Mpa, CO 2 The flow rate is 12L / h, the extraction time is 4h, and the extract is collected to obtain the product.

[0045] 2) Weigh 4.5 kg of Andrographis paniculata according to the proportioning ratio, then reflux and extract 2 times with 90% ethanol, add ethanol with a volume 7 times the weight of Andrographis paniculata for the first time, continuously reflux for 3.5 hours, release the extract, add the weight of...

Embodiment 2

[0049] Embodiment 2: Chinese medicine composition with antibacterial and anti-inflammatory effects

[0050] 1. Composition: Angelica 11.25kg, Codonopsis 11.25kg, Andrographis paniculata 11.25kg, Dianmianzhen 11.25kg, Rosa root 20kg, Millipeda spathifolia 20kg, Gonggong wood 20kg, and Qianjinba 20kg.

[0051] 2. Extraction method:

[0052] 1) Weigh 11.25kg of Angelica sinensis according to the proportion, extract with 1.125L (0.1 times the volume of Angelica sinensis weight) concentration of 80% ethanol, the extraction temperature is 40°C, the extraction pressure is 25Mpa, the analytical pressure is 8Mpa, CO 2 The flow rate is 10L / h, the extraction time is 4h, and the extract is collected to obtain the product.

[0053] 2) Weigh 11.25 kg of Andrographis paniculata according to the proportioning ratio, then reflux and extract 2 times with 80% ethanol, add ethanol with a volume 6 times the weight of Andrographis paniculata for the first time, continuously reflux for 4 hours, rel...

Embodiment 3

[0057] Embodiment 3: Chinese medicine composition with antibacterial and anti-inflammatory effects

[0058] 1. Composition: Angelica 9kg, Codonopsis 9kg, Andrographis paniculata 9kg, Dianmianzhen 9kg, Rosa root 16kg, Caulis Spatholobus 16kg, Gonggongmu 16kg, Qianjinba 16kg.

[0059] 2. Extraction method:

[0060] 1) Take 9kg of Angelica sinensis according to the proportion, extract with 95% ethanol of 1.8L (0.2 times the volume of Angelica sinensis weight), the extraction temperature is 40°C, the extraction pressure is 30Mpa, the analytical pressure is 10Mpa, CO 2 The flow rate is 12L / h, the extraction time is 3h, and the extract is collected to obtain the product.

[0061] 2) Take 9 kg of Andrographis paniculata according to the proportioning, extract 2 times with 85% ethanol reflux, add the ethanol of 7 times the volume of Andrographis paniculata weight for the first time, reflux continuously for 3 hours, release the extract, add 6% of the weight of Andrographis paniculata ...

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Abstract

The invention relates to a traditional Chinese medicinal composition with antimicrobial and antiinflammation effects and a preparation method thereof. The traditional Chinese medicinal composition with the antimicrobial and antiinflammation effects is prepared from the following components in parts by weight: 9 parts of Chinese angelica, 9 parts of codonopsis pilosula, 9 parts of common andrographis herb, 9 parts of zanthoxylum dissitum, 16 parts of cherokee rose root, 16 parts of caulis spatholobi, 16 parts of Chinese mahonia stem and 16 parts of philippine flemingia root; and the preparation method of the traditional Chinese medicinal composition with the antimicrobial and antiinflammation effects comprises the following steps: carrying out supercritical extraction on Chinese angelica, extracting common andrographis herb with ethanol, extracting zanthoxylum dissitum and Chinese mahonia stem with water, extracting philippine flemingia root with ethanol, extracting Cherokee rose root, caulis spatholobi and codonopsis pilosula with water, mixing extracting solutions, concentrating and drying, so that the traditional Chinese medicinal composition is obtained. Experiments verify that the traditional Chinese medicinal composition provided by the invention has antimicrobial and antiinflammation effects and especially has a definite chronic pharyngolaryngitis treating effect better than that of the prior art.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with antibacterial and anti-inflammatory effects and a preparation method thereof, in particular to a traditional Chinese medicine composition capable of treating chronic pharyngitis and a preparation method thereof. Background technique [0002] Chronic pharyngitis is a diffuse pharyngeal lesion caused by chronic infection. It occurs more frequently in adults and is a common disease with a very high incidence. The main causes include long-term dust or harmful gas stimulation, sinusitis secretion stimulation, repeated acute pharyngitis, allergic constitution or weakened body resistance, etc. [0003] Chronic pharyngitis, also known as chronic pharyngitis, is more common. The lesions are mainly in the mucosal layer, manifested as chronic congestion of the pharyngeal mucosa, with more lymphocyte infiltration around the blood v...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K36/738A61P31/04A61P29/00A61P11/04
CPCA61K36/19A61K36/232A61K36/29A61K36/344A61K36/48A61K36/486A61K36/738A61K36/758A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 龚云张素英颜利玲李三新
Owner ZHUZHOU QIANJIN PHARMA
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